Reactome | RRAGC,D hydrolyzes GTP

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RRAGC,D hydrolyzes GTP Show undefined attributes

authored	[InstanceEdit:9645589] May, Bruce, 2019-05-06
catalystActivity	[CatalystActivity:9645592] GTPase activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9645591] May, Bruce, 2019-05-13
dbId	9645598
displayName	RRAGC,D hydrolyzes GTP
edited	[InstanceEdit:9645589] May, Bruce, 2019-05-06
eventOf	[Pathway:R-HSA-9639288] Amino acids regulate mTORC1 - Homo sapiens
input	[Complex:R-HSA-9640174] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9640261] The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 [LiteratureReference:9646242] Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases [LiteratureReference:9646247] Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RRAGC,D hydrolyzes GTP
orthologousEvent	[Reaction:R-SCE-9645598] RRAGC,D hydrolyzes GTP - Saccharomyces cerevisiae [Reaction:R-SPO-9645598] RRAGC,D hydrolyzes GTP - Schizosaccharomyces pombe [Reaction:R-DDI-9645598] RRAGC,D hydrolyzes GTP - Dictyostelium discoideum [Reaction:R-CEL-9645598] RRAGC,D hydrolyzes GTP - Caenorhabditis elegans [Reaction:R-DME-9645598] RRAGC,D hydrolyzes GTP - Drosophila melanogaster [Reaction:R-GGA-9645598] RRAGC,D hydrolyzes GTP - Gallus gallus [Reaction:R-XTR-9645598] RRAGC,D hydrolyzes GTP - Xenopus tropicalis [Reaction:R-DRE-9645598] RRAGC,D hydrolyzes GTP - Danio rerio [Reaction:R-SSC-9645598] RRAGC,D hydrolyzes GTP - Sus scrofa [Reaction:R-BTA-9645598] RRAGC,D hydrolyzes GTP - Bos taurus [Reaction:R-CFA-9645598] RRAGC,D hydrolyzes GTP - Canis familiaris [Reaction:R-RNO-9645598] RRAGC,D hydrolyzes GTP - Rattus norvegicus [Reaction:R-MMU-9645598] RRAGC,D hydrolyzes GTP - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-9640184] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Homo sapiens
regulatedBy	[PositiveRegulation:9645588] Positive regulation by 'FLCN:FNIP1,2 [cytosol]'
regulationReference	[RegulationReference:9647716] Positive regulation by 'FLCN:FNIP1,2 [cytosol]' Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9645598
summation	[Summation:9645597] RRAGC (RagC) and RRAGD (RagD) are guanyl nucleotide-binding ...

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[Pathway:R-HSA-9639288] Amino acids regulate mTORC1

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