Reactome | Amino acids regulate mTORC1

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Amino acids regulate mTORC1 Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331815
displayName	Amino acids regulate mTORC1
eventOf	[Pathway:R-CFA-9711097] Cellular response to starvation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:258409] cellular response to amino acid starvation
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-CFA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Canis familiaris [BlackBoxEvent:R-CFA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Canis familiaris [BlackBoxEvent:R-CFA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Canis familiaris [BlackBoxEvent:R-CFA-9640254] BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 - Canis familiaris [Reaction:R-CFA-9639286] RRAGC,D exchanges GTP for GDP - Canis familiaris [Reaction:R-CFA-9645598] RRAGC,D hydrolyzes GTP - Canis familiaris [Reaction:R-CFA-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Canis familiaris [Reaction:R-CFA-9640167] RRAGA,B exchanges GDP for GTP - Canis familiaris [Reaction:R-CFA-9640168] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine - Canis familiaris [Reaction:R-CFA-9645608] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 - Canis familiaris [Reaction:R-CFA-9646468] mTORC1 binds RHEB:GTP - Canis familiaris [Reaction:R-CFA-9640195] RRAGA,B hydrolyzes GTP - Canis familiaris
inferredFrom	[Pathway:R-HSA-9639288] Amino acids regulate mTORC1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Amino acids regulate mTORC1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-9639288
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9711097] Cellular response to starvation
(inferredTo)	[Pathway:R-HSA-9639288] Amino acids regulate mTORC1

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