Reactome | v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine

Schema > Reaction > Entries

v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine Show undefined attributes

authored	[InstanceEdit:9640182] May, Bruce, 2019-03-23
category	binding
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9640178] May, Bruce, 2019-03-23
dbId	9640175
displayName	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine
edited	[InstanceEdit:9640182] May, Bruce, 2019-03-23
eventOf	[Pathway:R-HSA-9639288] Amino acids regulate mTORC1 - Homo sapiens
followingEvent	[Reaction:R-HSA-9640167] RRAGA,B exchanges GDP for GTP - Homo sapiens
input	[Complex:R-HSA-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-HSA-9640184] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9640284] Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms [LiteratureReference:8952709] Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 [LiteratureReference:9646226] mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient [LiteratureReference:8952719] SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine
orthologousEvent	[Reaction:R-CEL-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Caenorhabditis elegans [Reaction:R-GGA-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Gallus gallus [Reaction:R-DRE-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Danio rerio [Reaction:R-SSC-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Sus scrofa [Reaction:R-BTA-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Bos taurus [Reaction:R-CFA-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Canis familiaris [Reaction:R-RNO-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Rattus norvegicus [Reaction:R-MMU-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Mus musculus
output	[Complex:R-HSA-9640192] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane]
precedingEvent	[Reaction:R-HSA-9639286] RRAGC,D exchanges GTP for GDP - Homo sapiens
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9657680] Condon, Kendall J, Sabatini, David M, 2019-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9640175
summation	[Summation:9646225] The N-terminal domain of SLC38A9 bound to L-arginine interac...

Referrals

(hasEvent)	[Pathway:R-HSA-9639288] Amino acids regulate mTORC1
(precedingEvent)	[Reaction:R-HSA-9640167] RRAGA,B exchanges GDP for GTP