RRAGC,D exchanges GTP for GDP

Stable Identifier
R-HSA-9639286
Type
Reaction [transition]
Species
Homo sapiens
Compartment
lysosomal membrane
ReviewStatus
5/5
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RRAGC,D exchanges GTP for GDP
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The Ragulator complex acts as an unconventional guanyl nucleotide exchange factor (GEF) that ejects GTP from RRAGC and, by inference, RRAGD (Shen and Sabatini 2018). (Other known GEFs cause ejection of GDP rather than GTP from their targets.) The GDP-bound form of RRAGC,D is the active form that recruits mTORC1 to the lysosomal membrane.
Literature References
PubMed ID Title Journal Year
30181260 Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

Shen, K, Sabatini, DM

Proc. Natl. Acad. Sci. U.S.A. 2018
Participants
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Output
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as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane]

Physical Entity
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
RRAGC,D exchanges GTP for GDP (Bos taurus)
RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)
RRAGC,D exchanges GTP for GDP (Canis familiaris)
RRAGC,D exchanges GTP for GDP (Danio rerio)
RRAGC,D exchanges GTP for GDP (Dictyostelium discoideum)
RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)
RRAGC,D exchanges GTP for GDP (Gallus gallus)
RRAGC,D exchanges GTP for GDP (Mus musculus)
RRAGC,D exchanges GTP for GDP (Rattus norvegicus)
RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)
RRAGC,D exchanges GTP for GDP (Schizosaccharomyces pombe)
RRAGC,D exchanges GTP for GDP (Sus scrofa)
RRAGC,D exchanges GTP for GDP (Xenopus tropicalis)
Authored
May, B  (2019-03-04)
Reviewed
Condon, KJ  (2019-08-08)
Sabatini, DM  (2019-08-08)
Created
May, B  (2019-03-09)
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