Reactome | PGM1:Mg2+ isomerises G1P to G6P

Schema > Reaction > Entries

PGM1:Mg2+ isomerises G1P to G6P Show undefined attributes

catalystActivity	[CatalystActivity:9638129] phosphoglucomutase activity of PGM1:Mg2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9638128] Jassal, Bijay, 2019-02-25
crossReference	[DatabaseIdentifier:12667686] RHEA:23537 [DatabaseIdentifier:9931468] RHEA:23537
dbId	9638125
deleted	[Deleted:9772128] Deletion of instance: 70427
displayName	PGM1:Mg2+ isomerises G1P to G6P
edited	[InstanceEdit:8955629] Jassal, Bijay, 2017-01-12
eventOf	[Pathway:R-HSA-70370] Galactose catabolism - Homo sapiens [Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis) - Homo sapiens
followingEvent	[Reaction:R-HSA-198513] SLC7A4 exchanges G6P for Pi across the ER membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29548] G1P [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199695] The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination [LiteratureReference:9772124] A kinetic study of the isozymes determined by the three human phosphoglucomutase loci PGM1, PGM2, and PGM3
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PGM1:Mg2+ isomerises G1P to G6P alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate
negativePrecedingEvent	[NegativePrecedingEvent:9931450] Futile Cycle: PGM1:Mg2+ isomerises G6P to G1P
orthologousEvent	[Reaction:R-DRE-9638125] PGM1:Mg2+ isomerises G1P to G6P - Danio rerio [Reaction:R-SCE-9638125] PGM1:Mg2+ isomerises G1P to G6P - Saccharomyces cerevisiae [Reaction:R-SPO-9638125] PGM1:Mg2+ isomerises G1P to G6P - Schizosaccharomyces pombe [Reaction:R-DDI-9638125] PGM1:Mg2+ isomerises G1P to G6P - Dictyostelium discoideum [Reaction:R-CEL-9638125] PGM1:Mg2+ isomerises G1P to G6P - Caenorhabditis elegans [Reaction:R-DME-9638125] PGM1:Mg2+ isomerises G1P to G6P - Drosophila melanogaster [Reaction:R-GGA-9638125] PGM1:Mg2+ isomerises G1P to G6P - Gallus gallus [Reaction:R-RNO-9638125] PGM1:Mg2+ isomerises G1P to G6P - Rattus norvegicus [Reaction:R-MMU-9638125] PGM1:Mg2+ isomerises G1P to G6P - Mus musculus
output	[SimpleEntity:R-ALL-30537] G6P [cytosol]
precedingEvent	[Reaction:R-HSA-70449] GADPH tetramer dehydrogenates GA3P - Homo sapiens [Reaction:R-HSA-71515] glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] - Homo sapiens [Reaction:R-HSA-71590] glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] - Homo sapiens [Reaction:R-HSA-453358] poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] - Homo sapiens [Reaction:R-HSA-453339] poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] - Homo sapiens [Reaction:R-HSA-70361] GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9936506] D'Eustachio, Peter, 2025-01-23
revised	[InstanceEdit:8955629] Jassal, Bijay, 2017-01-12 [InstanceEdit:453329] D'Eustachio, P, 2010-01-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9638125
summation	[Summation:70273] Cytosolic phosphoglucomutase 1 (PGM1) catalyzes the reversib...
updateTrackers	[UpdateTracker:9774837] Update Tracker - [Reaction:9638125] PGM1:Mg2+ isomerises G1P to G6P - v81:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9774837] Update Tracker - [Reaction:9638125] PGM1:Mg2+ isomerises G1P to G6P - v81:[add_removeLiteratureReference, modifyText]
(replacementInstances)	[Deleted:9772128] Deletion of instance: 70427
(hasEvent)	[Pathway:R-HSA-70370] Galactose catabolism [Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis)
(precedingEvent)	[NegativePrecedingEvent:9983808] Abundant Molecules: PGM1:Mg2+ isomerises G1P to G6P [Reaction:R-HSA-198513] SLC7A4 exchanges G6P for Pi across the ER membrane [NegativePrecedingEvent:9931467] Futile Cycle: PGM1:Mg2+ isomerises G1P to G6P

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