Reactome | PGM1:Mg2+ isomerises G1P to G6P

PGM1:Mg2+ isomerises G1P to G6P

Stable Identifier

R-HSA-9638125

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate, D-Glucose 1-phosphate <=> alpha-D-Glucose 6-phosphate

ReviewStatus

5/5

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Cytosolic phosphoglucomutase 1 (PGM1) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two PGM isoenzymes, both monomers, have been identified. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Quick et al. 1974).

Literature References

PubMed ID	Title	Journal	Year
7902568	The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination March, RE, Putt, W, Hollyoake, M, Ives, JH, Lovegrove, JU, Hopkinson, DA, Edwards, YH, Whitehouse, DB	Proc Natl Acad Sci U S A	1993
4829444	A kinetic study of the isozymes determined by the three human phosphoglucomutase loci PGM1, PGM2, and PGM3 Quick, CB, Fisher, RA, Harris, H	Eur J Biochem	1974