Reactome | poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]

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poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] Show undefined attributes

authored	[InstanceEdit:453329] D'Eustachio, P, 2010-01-21
catalystActivity	[CatalystActivity:71514] glycogen phosphorylase activity of active PYGM and PYGB dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:453352] D'Eustachio, P, 2010-01-21
crossReference	[DatabaseIdentifier:9931451] RHEA:41733
dbId	453358
deleted	[Deleted:453373] Deletion of instances: 71596, 71595, 71555, 71554 [Deleted:453369] Deletion of instance: 70216
displayName	poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
eventOf	[Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis) - Homo sapiens
followingEvent	[Reaction:R-HSA-9638125] PGM1:Mg2+ isomerises G1P to G6P - Homo sapiens
inferredFrom	[Reaction:R-HSA-71590] glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] - Homo sapiens
input	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-453217] poly((1,4)-alpha-glucosyl)GYG1 dimer [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:453326] Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core [LiteratureReference:453361] The family of glycogen phosphorylases: structure and function
maxDepth	1
modified	[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
name	poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] ((1->4)-alpha-D-glucosyl)(n) + phosphate => ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate
output	[SimpleEntity:R-ALL-29548] G1P [cytosol] [Complex:R-HSA-70203] GYG1 dimer [cytosol]
precedingEvent	[Reaction:R-HSA-453337] glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP - Homo sapiens [Reaction:R-HSA-71541] glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP - Homo sapiens [Reaction:R-HSA-453356] PYGB dimer, b form + 2 AMP => PYGB b dimer:AMP complex - Homo sapiens [Reaction:R-HSA-453342] PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex - Homo sapiens [Reaction:R-HSA-71593] ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-453358
summation	[Summation:453341] The PYGM and PYGB forms of glycogen phosphorylase catalyze t...

Referrals

(replacementInstances)	[Deleted:453373] Deletion of instances: 71596, 71595, 71555, 71554 [Deleted:453369] Deletion of instance: 70216
(precedingEvent)	[NegativePrecedingEvent:9931452] Abundant Molecules: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] [Reaction:R-HSA-9638125] PGM1:Mg2+ isomerises G1P to G6P
(hasEvent)	[Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis)
(inferredTo)	[Reaction:R-HSA-71590] glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]

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