Reactome | Galactose catabolism

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Galactose catabolism Show undefined attributes

authored	[InstanceEdit:70156] 2003-02-25 00:00:00
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12819595] BioModels Database:BIOMD0000000579
dbId	70370
diseasePathways	[Pathway:R-HSA-5609978] Defective GALT can cause GALCT - Homo sapiens [Pathway:R-HSA-9931929] Defective GALM causes GALAC4 - Homo sapiens [Pathway:R-HSA-5609976] Defective GALK1 causes GALCT2 - Homo sapiens [Pathway:R-HSA-5609977] Defective GALE causes EDG - Homo sapiens
displayName	Galactose catabolism
doi	10.3180/REACT_532.1
eventOf	[Pathway:R-HSA-71387] Metabolism of carbohydrates and carbohydrate derivatives - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263513] galactose catabolic process via UDP-galactose, Leloir pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Homo sapiens [Reaction:R-HSA-70355] GALK1 phosphorylates Gal to Gal1P - Homo sapiens [Reaction:R-HSA-70361] GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal - Homo sapiens [Reaction:R-HSA-9638125] PGM1:Mg2+ isomerises G1P to G6P - Homo sapiens [Reaction:R-HSA-70369] GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc - Homo sapiens [Reaction:R-HSA-9931850] AKR1B1 reduces galactose to galactitol - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[Book:70364] 0071163360 Scriver, Charles R Galactosemia The Metabolic & Molecular Bases of Inherited Disease [LiteratureReference:70357] The molecular biology of galactosemia
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Galactose catabolism
orthologousEvent	[Pathway:R-BTA-70370] Galactose catabolism - Bos taurus [Pathway:R-SCE-70370] Galactose catabolism - Saccharomyces cerevisiae [Pathway:R-SPO-70370] Galactose catabolism - Schizosaccharomyces pombe [Pathway:R-DDI-70370] Galactose catabolism - Dictyostelium discoideum [Pathway:R-CEL-70370] Galactose catabolism - Caenorhabditis elegans [Pathway:R-DME-70370] Galactose catabolism - Drosophila melanogaster [Pathway:R-GGA-70370] Galactose catabolism - Gallus gallus [Pathway:R-XTR-70370] Galactose catabolism - Xenopus tropicalis [Pathway:R-DRE-70370] Galactose catabolism - Danio rerio [Pathway:R-SSC-70370] Galactose catabolism - Sus scrofa [Pathway:R-CFA-70370] Galactose catabolism - Canis familiaris [Pathway:R-RNO-70370] Galactose catabolism - Rattus norvegicus [Pathway:R-MMU-70370] Galactose catabolism - Mus musculus
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9936506] D'Eustachio, Peter, 2025-01-23
revised	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-70370
summation	[Summation:70371] The main sources of galactose in the human diet are milk and...
updateTrackers	[UpdateTracker:9786325] Update Tracker - [Pathway:70370] Galactose catabolism - v50:[updateContainedRLE] [UpdateTracker:9787779] Update Tracker - [Pathway:70370] Galactose catabolism - v44:[addHasEvent] [UpdateTracker:9785166] Update Tracker - [Pathway:70370] Galactose catabolism - v52:[updateContainedRLE] [UpdateTracker:9774631] Update Tracker - [Pathway:70370] Galactose catabolism - v81:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9939800] Update Tracker - [Pathway:70370] Galactose catabolism - v92:[removeHasEvent] [UpdateTracker:9790946] Update Tracker - [Pathway:70370] Galactose catabolism - v32:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9792376] Update Tracker - [Pathway:70370] Galactose catabolism - v22:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9786325] Update Tracker - [Pathway:70370] Galactose catabolism - v50:[updateContainedRLE] [UpdateTracker:9787779] Update Tracker - [Pathway:70370] Galactose catabolism - v44:[addHasEvent] [UpdateTracker:9785166] Update Tracker - [Pathway:70370] Galactose catabolism - v52:[updateContainedRLE] [UpdateTracker:9774631] Update Tracker - [Pathway:70370] Galactose catabolism - v81:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9939800] Update Tracker - [Pathway:70370] Galactose catabolism - v92:[removeHasEvent] [UpdateTracker:9790946] Update Tracker - [Pathway:70370] Galactose catabolism - v32:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9792376] Update Tracker - [Pathway:70370] Galactose catabolism - v22:[updateContainedRLE]
(normalPathway)	[Pathway:R-HSA-5609978] Defective GALT can cause GALCT [Pathway:R-HSA-9931929] Defective GALM causes GALAC4 [Pathway:R-HSA-5609976] Defective GALK1 causes GALCT2 [Pathway:R-HSA-5609977] Defective GALE causes EDG
(hasEvent)	[Pathway:R-HSA-71387] Metabolism of carbohydrates and carbohydrate derivatives

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