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Entries
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+
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catalystActivity
[CatalystActivity:70448] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramers [cytosol]
catalystActivityReference
[CatalystActivityReference:9644037] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramers [cytosol] Glyceraldehyde-3-phosphate dehydrogenase from human tissues
category
transition
compartment
[Compartment:70101] cytosol
crossReference
[DatabaseIdentifier:11880706] Rhea:10301
dbId
70449
displayName
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+
eventOf
[Pathway:R-HSA-70171] Glycolysis - Homo sapiens
followingEvent
[Reaction:R-HSA-6798335] BPGM dimer isomerises 1,3BPG to 2,3BPG - Homo sapiens
[Reaction:R-HSA-9638125] PGM1:Mg2+ isomerises G1P to G6P - Homo sapiens
[Reaction:R-HSA-71850] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP - Homo sapiens
[Reaction:R-HSA-9856871] MDH1 reduces OA - Homo sapiens
input
[SimpleEntity:R-ALL-29578] GA3P [cytosol]
[SimpleEntity:R-ALL-29360] NAD+ [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:70430] Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations
[LiteratureReference:71644] Crystalline D-glyceraldehyde-3-phosphate dehydrogenase from rabbit muscle
[LiteratureReference:70436] Isozymes of glyceraldehyde 3-phosphate dehydrogenase in man and other mammals
[LiteratureReference:141459] Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene
[LiteratureReference:70433] Glyceraldehyde-3-phosphate dehydrogenase from human tissues
[LiteratureReference:70439] Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells
[LiteratureReference:71647] The prosthetic group of crystalline d-glyceraldehyde-3-phosphate dehydrogenase
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+
Glyceraldehyde 3 phosphate, NAD+, and orthophosphate react to form 1,3 bisphosphoglycerate and NADH + H+
orthologousEvent
[Reaction:R-PFA-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Plasmodium falciparum
[Reaction:R-SCE-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Saccharomyces cerevisiae
[Reaction:R-SPO-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Schizosaccharomyces pombe
[Reaction:R-DDI-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Dictyostelium discoideum
[Reaction:R-CEL-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Caenorhabditis elegans
[Reaction:R-DME-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Drosophila melanogaster
[Reaction:R-GGA-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Gallus gallus
[Reaction:R-XTR-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Xenopus tropicalis
[Reaction:R-DRE-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Danio rerio
[Reaction:R-SSC-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Sus scrofa
[Reaction:R-BTA-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Bos taurus
[Reaction:R-CFA-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Canis familiaris
[Reaction:R-RNO-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Rattus norvegicus
[Reaction:R-MMU-70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - Mus musculus
output
[SimpleEntity:R-ALL-29800] 1,3BPG [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent
[Reaction:R-HSA-70454] dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate - Homo sapiens
[Reaction:R-HSA-70349] DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate - Homo sapiens
releaseDate
2004-07-06
reverseReaction
[Reaction:R-HSA-70482] GAPDH tetramers reduce 1,3BPG to GA3P
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:450685] D'Eustachio, P, 2009-12-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70449
summation
[Summation:71510] Cytosolic glyceraldehyde 3-phosphate dehydrogenase catalyzes...
Referrals
(precedingEvent)
[Reaction:R-HSA-6798335] BPGM dimer isomerises 1,3BPG to 2,3BPG
[Reaction:R-HSA-9638125] PGM1:Mg2+ isomerises G1P to G6P
[Reaction:R-HSA-9856871] MDH1 reduces OA
[Reaction:R-HSA-71850] 1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP
(hasEvent)
[Pathway:R-HSA-70171] Glycolysis
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