PRKCZ recruits RAS in response to estrogen stimulation

Stable Identifier
Reaction [binding]
Homo sapiens
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RAS is recruited to a complex that also contains SRC, PRKCZ and the p85 subunit of PI3K in response to estrogen stimulation (Castoria et al, 2004). RAS signaling downstream of ESR1 contributes to cell cycle progression through the induction of cyclin D transcription and the nuclear export of CDKN1B (Castoria et al, 1999; Castoria et al, 2001; Migliaccio et al, 1996; Rodier et al, 2002; reviewed in Castoria et al, 2010; Arnal et al, 2017).

Literature References
PubMed ID Title Journal Year
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Katzenellenbogen, B, Chambon, P, Flouriot, G, M├ętivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M

Physiol. Rev. 2017
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Auricchio, F, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

Mol. Cell. Biol. 2004
8635462 Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells

Auricchio, F, Bontempo, P, Di Domenico, M, de Falco, A, Nola, E, Castoria, G, Migliaccio, A

EMBO J. 1996
19879889 Cell proliferation regulated by estradiol receptor: Therapeutic implications

Auricchio, F, Giovannelli, P, Castoria, G, Migliaccio, A

Steroids 2010
10228164 Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

Auricchio, F, Migliaccio, A, Castoria, G, Di Domenico, M, Barone, MV, Bilancio, A, Ametrano, D

EMBO J. 1999
11726503 p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

Meloche, S, Coulombe, P, Rodier, G, Montagnoli, A, Di Marcotullio, L, Pagano, M, Draetta, GF

EMBO J. 2001
11689445 PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

EMBO J. 2001
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