p-S10 CDKN1B translocates to the cytosol

Stable Identifier
R-HSA-9632873
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Estrogen stimulation causes a partial redistribution of CDKN1B into the cytosol in a manner that depends on Ras and PI3K signaling and the atypical PKC zeta (Rodier et al, 2002; Castoria et al, 2004). Nuclear localization of CDKN1B inhibits cell cycle progression (Reynisdottir et al, 1997).

Literature References
PubMed ID Title Journal Year
11726503 p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

Rodier, G, Montagnoli, A, Di Marcotullio, L, Coulombe, P, Draetta, GF, Pagano, M, Meloche, S

EMBO J. 2001
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Castoria, G, Migliaccio, A, Di Domenico, M, Lombardi, M, de Falco, A, Varricchio, L, Bilancio, A, Barone, MV, Auricchio, F

Mol. Cell. Biol. 2004
9042862 The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

Reynisdóttir, I, Massagué, J

Genes Dev. 1997
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