Reactome | p-S10 CDKN1B translocates to the cytosol

p-S10 CDKN1B translocates to the cytosol

Stable Identifier

R-HSA-9632873

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytoplasm

ReviewStatus

5/5

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p-S10 CDKN1B translocates to the cytosol

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Estrogen stimulation causes a partial redistribution of CDKN1B into the cytosol in a manner that depends on Ras and PI3K signaling and the atypical PKC zeta (Rodier et al, 2002; Castoria et al, 2004). Nuclear localization of CDKN1B inhibits cell cycle progression (Reynisdottir et al, 1997).

Literature References

PubMed ID	Title	Journal	Year
15314172	Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells Castoria, G, Migliaccio, A, Di Domenico, M, Lombardi, M, de Falco, A, Varricchio, L, Bilancio, A, Barone, MV, Auricchio, F	Mol. Cell. Biol.	2004
11726503	p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis Rodier, G, Montagnoli, A, Di Marcotullio, L, Coulombe, P, Draetta, GF, Pagano, M, Meloche, S	EMBO J.	2001
9042862	The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2 Reynisdóttir, I, Massagué, J	Genes Dev.	1997