p-S10 CDKN1B translocates to the cytosol

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Estrogen stimulation causes a partial redistribution of CDKN1B into the cytosol in a manner that depends on Ras and PI3K signaling and the atypical PKC zeta (Rodier et al, 2002; Castoria et al, 2004). Nuclear localization of CDKN1B inhibits cell cycle progression (Reynisdottir et al, 1997).

Literature References
PubMed ID Title Journal Year
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Auricchio, F, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

Mol. Cell. Biol. 2004
11726503 p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

Meloche, S, Coulombe, P, Rodier, G, Montagnoli, A, Di Marcotullio, L, Pagano, M, Draetta, GF

EMBO J. 2001
9042862 The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

Reynisdóttir, I, Massagué, J

Genes Dev. 1997
This event is regulated