Reactome | PTK2 autophosphorylates downstream of EGFR

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PTK2 autophosphorylates downstream of EGFR Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
catalystActivity	[CatalystActivity:9625454] protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9625486] Rothfels, Karen, 2018-10-19
dbId	9625487
displayName	PTK2 autophosphorylates downstream of EGFR
eventOf	[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9625255] FAK integrates growth-factor and integrin signals to promote cell migration [LiteratureReference:9625310] The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway [LiteratureReference:9625244] Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor ? (ER?) [LiteratureReference:9625283] Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer [LiteratureReference:9625294] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells [LiteratureReference:9623987] The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells [LiteratureReference:9623938] 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PTK2 autophosphorylates downstream of EGFR
orthologousEvent	[Reaction:R-CEL-9625487] PTK2 autophosphorylates downstream of EGFR - Caenorhabditis elegans [Reaction:R-BTA-9625487] PTK2 autophosphorylates downstream of EGFR - Bos taurus [Reaction:R-CFA-9625487] PTK2 autophosphorylates downstream of EGFR - Canis familiaris [Reaction:R-RNO-9625487] PTK2 autophosphorylates downstream of EGFR - Rattus norvegicus [Reaction:R-MMU-9625487] PTK2 autophosphorylates downstream of EGFR - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9625482] PTK2 binds activated EGFR - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9625487
summation	[Summation:9625476] Stimulation of cells with either E2 (beta-estradiol), tamoxi...

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[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling

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