Reactome | EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9625468] Rothfels, Karen, 2018-10-19
dbId	9625464
displayName	EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]
hasComponent	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-354068] p-Y397-PTK2 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] - Mus musculus [Complex:R-RNO-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] - Canis familiaris [Complex:R-BTA-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] - Bos taurus [Complex:R-CEL-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] - Caenorhabditis elegans
isChimeric	false
maxDepth	4
name	EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2
positivelyRegulates	[PositiveRegulation:9625463] Positive regulation by 'EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]'
producedByEvent	[Reaction:R-HSA-9625487] PTK2 autophosphorylates downstream of EGFR - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9625464

(regulator)	[PositiveRegulation:9625463] Positive regulation by 'EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]'
(activeUnit)	[PositiveRegulation:9625463] Positive regulation by 'EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]'
(output)	[Reaction:R-HSA-9625487] PTK2 autophosphorylates downstream of EGFR

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