PTK2 autophosphorylates downstream of EGFR

Stable Identifier
Reaction [transition]
Homo sapiens
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Stimulation of cells with either E2 (beta-estradiol), tamoxifen or G1 (a GPER1 agonist) enhances EGFR-dependent FAK autophosphorylation at Y397 (Sieg et al, 2000; Liu et al, 2010; Tsai et al, 2013). Signaling occurs through both GPER1 and ER alpha (ESR1) and induces cell proliferation and migration through the EGFR-PI3K-ERK pathway (Liu et al, 2010; Tsai et al, 2013; reviewed in Zhu et al, 2018). FAK autophosphorylation is also required for FOS (c-fos) induction downstream of E2 (Liu et al, 2010; Tsai et al, 2013; Maggiolini et al, 2004; Vivacqua et al, 2006a,b).
Literature References
PubMed ID Title Journal Year
24039841 Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor α (ERα)

Lin, CY, Hsueh, S, Chao, A, Lin, YJ, Wang, HS, Tsai, CL, Lai, CH, Wang, TH, Wu, HM

PLoS ONE 2013
15090535 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells

Maggiolini, M, Musti, AM, Montanaro, D, Sisci, D, Picard, D, Recchia, AG, Andó, S, Fasanella, G, Vivacqua, A, Pezzi, V

J. Biol. Chem. 2004
20650261 The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway

Yao, W, Zha, X, Shi, Y, Cai, X, Mei, C, Sun, L, Liu, M, Qiu, S, Liu, Y, Wang, C, Fan, J, Yang, Y

Arch. Biochem. Biophys. 2010
10806474 FAK integrates growth-factor and integrin signals to promote cell migration

Sieg, DJ, Klingbeil, CK, Damsky, CH, Hauck, CR, Ilic, D, Schlaepfer, DD, Schaefer, E

Nat. Cell Biol. 2000
16239258 The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells

Maggiolini, M, Musti, AM, Picard, D, Bonofiglio, D, Recchia, AG, Andó, S, Vivacqua, A

Mol. Endocrinol. 2006
29738483 Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer

Zhu, X, Guo, Y, Yang, W, Bao, Y

Cancers (Basel) 2018
16835357 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30

Maggiolini, M, Musti, AM, Carpino, A, Rago, V, Picard, D, Madeo, A, Bonofiglio, D, Albanito, L, Andó, S, Vivacqua, A

Mol. Pharmacol. 2006
Catalyst Activity

protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]

Orthologous Events
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