Reactome | PTK2 autophosphorylates downstream of EGFR

Schema > Reaction > Entries

PTK2 autophosphorylates downstream of EGFR Show undefined attributes

catalystActivity	[CatalystActivity:10318690] protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10318692
displayName	PTK2 autophosphorylates downstream of EGFR
eventOf	[Pathway:R-CFA-9009391] Extra-nuclear estrogen signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9625487] PTK2 autophosphorylates downstream of EGFR - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PTK2 autophosphorylates downstream of EGFR
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]
precedingEvent	[Reaction:R-CFA-9625482] PTK2 binds activated EGFR - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9625487
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9009391] Extra-nuclear estrogen signaling
(inferredTo)	[Reaction:R-HSA-9625487] PTK2 autophosphorylates downstream of EGFR

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