Reactome | EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:9625454] protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-9625487] PTK2 autophosphorylates downstream of EGFR - Homo sapiens
created	[InstanceEdit:9625455] Rothfels, Karen, 2018-10-19
dbId	9625453
displayName	EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
hasComponent	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-201621] PTK2 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] - Mus musculus [Complex:R-RNO-9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] - Canis familiaris [Complex:R-BTA-9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] - Bos taurus [Complex:R-CEL-9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:9625274] Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
maxDepth	4
name	EGF-like ligands:p-6Y EGFR:PTK2
producedByEvent	[Reaction:R-HSA-9625482] PTK2 binds activated EGFR - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9625453

(input)	[Reaction:R-HSA-9625487] PTK2 autophosphorylates downstream of EGFR
(physicalEntity)	[CatalystActivity:9625454] protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
(output)	[Reaction:R-HSA-9625482] PTK2 binds activated EGFR

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