Estrogen stimulation promotes cell cycle progression in a nu...

created [InstanceEdit:9623339] Rothfels, Karen, 2018-10-03
dbId 9623340
displayName Estrogen stimulation promotes cell cycle progression in a nu...
modified [InstanceEdit:9634617] Rothfels, Karen, 2019-01-11
schemaClass Summation
text Estrogen stimulation promotes cell cycle progression in a number of cell lines by upregulating the expression of the G1 cyclin CCND1 (Cyclin D1) (Castoria et al,1999; Castoria et al, 2001; reviewed in Castoria et al, 2010). Estrogen-responsive CCND1 expression is promoted through both the canonical ESR1 receptor and through the alternate receptor GPER1 (Castoria et al, 2001; Castoria et al, 2012; Kanda and Watanabe, 2003; Kanda and Watanabe, 2004). By electrophoretic mobility shift assay, phosphorylated CREB1 binds to a CRE element in the CCND1 promoter, and expression of a CRE-driven CCND1 reporter gene increases upon stimulation of cells with E2 (Kanda and Watanbe, 2003; Kanda and Watanabe, 2004). Expression of CCND1 downstream of E2 and ESR1 or GPER1 stimulates cellular proliferation, consistent with studies in other cell lines (Vivacqua et al, 2006a; Vivacqua et al, 2006b; Albanito et al, 2007; Albanito et al, 2008; Lin et al, 2009; Ariazi et al, 2010; reviewed in Filardo, 2018).
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