p-S133 CREB1 dimer binds the CCND1 promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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Estrogen stimulation promotes cell cycle progression in a number of cell lines by upregulating the expression of the G1 cyclin CCND1 (Cyclin D1) (Castoria et al,1999; Castoria et al, 2001; reviewed in Castoria et al, 2010). Estrogen-responsive CCND1 expression is promoted through both the canonical ESR1 receptor and through the alternate receptor GPER1 (Castoria et al, 2001; Castoria et al, 2012; Kanda and Watanabe, 2003; Kanda and Watanabe, 2004). By electrophoretic mobility shift assay, phosphorylated CREB1 binds to a CRE element in the CCND1 promoter, and expression of a CRE-driven CCND1 reporter gene increases upon stimulation of cells with E2 (Kanda and Watanbe, 2003; Kanda and Watanabe, 2004). Expression of CCND1 downstream of E2 and ESR1 or GPER1 stimulates cellular proliferation, consistent with studies in other cell lines (Vivacqua et al, 2006a; Vivacqua et al, 2006b; Albanito et al, 2007; Albanito et al, 2008; Lin et al, 2009; Ariazi et al, 2010; reviewed in Filardo, 2018).

Literature References
PubMed ID Title Journal Year
20086172 The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells

Ariazi, EA, Brailoiu, E, Yerrum, S, Shupp, HA, Slifker, MJ, Cunliffe, HE, Black, MA, Donato, AL, Arterburn, JB, Oprea, TI, Prossnitz, ER, Dun, NJ, Jordan, VC

Cancer Res. 2010
14675202 17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression

Kanda, N, Watanabe, S

J. Invest. Dermatol. 2003
15245432 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression

Kanda, N, Watanabe, S

J. Invest. Dermatol. 2004
19879889 Cell proliferation regulated by estradiol receptor: Therapeutic implications

Castoria, G, Migliaccio, A, Giovannelli, P, Auricchio, F

Steroids 2010
19549922 Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation

Lin, BC, Suzawa, M, Blind, RD, Tobias, SC, Bulun, SE, Scanlan, TS, Ingraham, HA

Cancer Res. 2009
18467441 Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells

Albanito, L, Sisci, D, Aquila, S, Brunelli, E, Vivacqua, A, Madeo, A, Lappano, R, Pandey, DP, Picard, D, Mauro, L, Andó, S, Maggiolini, M

Endocrinology 2008
28595943 A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis

Filardo, EJ

J. Steroid Biochem. Mol. Biol. 2018
16835357 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30

Vivacqua, A, Bonofiglio, D, Albanito, L, Madeo, A, Rago, V, Carpino, A, Musti, AM, Picard, D, Andó, S, Maggiolini, M

Mol. Pharmacol. 2006
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Castoria, G, Migliaccio, A, Di Domenico, M, Lombardi, M, de Falco, A, Varricchio, L, Bilancio, A, Barone, MV, Auricchio, F

Mol. Cell. Biol. 2004
17308128 G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells

Albanito, L, Madeo, A, Lappano, R, Vivacqua, A, Rago, V, Carpino, A, Oprea, TI, Prossnitz, ER, Musti, AM, Andó, S, Maggiolini, M

Cancer Res. 2007
10228164 Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

Castoria, G, Barone, MV, Di Domenico, M, Bilancio, A, Ametrano, D, Migliaccio, A, Auricchio, F

EMBO J. 1999
22266855 Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells

Castoria, G, Giovannelli, P, Lombardi, M, De Rosa, C, Giraldi, T, de Falco, A, Barone, MV, Abbondanza, C, Migliaccio, A, Auricchio, F

Oncogene 2012
16239258 The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells

Vivacqua, A, Bonofiglio, D, Recchia, AG, Musti, AM, Picard, D, Andó, S, Maggiolini, M

Mol. Endocrinol. 2006
11689445 PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

Castoria, G, Migliaccio, A, Bilancio, A, Di Domenico, M, de Falco, A, Lombardi, M, Fiorentino, R, Varricchio, L, Barone, MV, Auricchio, F

EMBO J. 2001
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