EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PMP22 gene expression is regulated during peripheral nerve myelination by the binding of EGR2 and SOX10 to upstream and intronic enhancer elements (Nagarajan et al, 2001; Maier et al, 2002; Maier et al, 2003; Jones et al, 2011; Srinivasan et al, 2012). Hippo signaling also influences PMP22 expression during peripheral never myelination by modulating the binding of the TEAD1, WWTR1 (also known as TAZ) and YAP1 to cognate sites in the PMP22 gene (Lopez-Anido et al, 2016; reviewed in Castelnovo et al, 2017).

Literature References
PubMed ID Title Journal Year
27288457 Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development

Law, WD, Antonellis, A, Lopez-Anido, C, Feltri, ML, Gopinath, C, Ma, KH, Moran, JJ, Svaren, J, Poitelon, Y

Hum. Mol. Genet. 2016
21411665 Regulation of the PMP22 gene through an intronic enhancer

Nagarajan, R, Jones, EA, Lopez-Anido, C, Chang, LW, Svaren, J, Srinivasan, R, Krueger, C

J. Neurosci. 2011
22492709 Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

Jones, EA, Keles, S, Sun, G, Moran, JJ, Svaren, J, Jang, SW, Srinivasan, R, Krueger, C

Nucleic Acids Res. 2012
12056842 Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves

Nave, KA, Berger, P, Suter, U, Maier, M

Mol. Cell. Neurosci. 2002
14664827 Distinct elements of the peripheral myelin protein 22 (PMP22) promoter regulate expression in Schwann cells and sensory neurons

Berger, P, Suter, U, Maier, M, Castagner, F

Mol. Cell. Neurosci. 2003
28852375 Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways

Colleoni, D, Ballabio, M, Castelnovo, LF, Melfi, S, Bonalume, V, Magnaghi, V

Neural Regen Res 2017
11394999 EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression

Milbrandt, J, Watson, M, Le, N, Svaren, J, Nagarajan, R, Araki, T

Neuron 2001
Cite Us!