Reactome | EGR2 gene expression

EGR2 gene expression

Stable Identifier

R-HSA-9613760

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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EGR2 (also known as KROX20) is a member of the Early Growth Response (EGR) gene family encoding sequence-specific Cys2-His2 DNA binding transcription factors. The EGR family are immediate early genes (IEGs) whose expression is rapidly upregulated in response to a number of external stimuli to control activation of genes involved in stress response and differentiation (reviewed in Pagel and Deindl, 2001; Bahrami and Drabløs, 2016). Roles for EGR proteins are well established in the nervous system, with EGR target genes contributing to synaptic plasticity, long-term potentiation, peripheral nerve myelination and NGF-induced neurite outgrowth (reviewed in Perez-Cadahia et al, 2011; Herdegen and Leah, 1998; O'Donovan et al, 1999)
In addition to its other roles, EGR2 is a critical regulator of myelination by Schwann cells in the peripheral nervous system (reviewed in Svaren and Meijer, 2008). Consistent with this, Schwann cells are blocked at the promyelinating stage in EGR2 knockouts in mice (Topilko et al, 1994). Expression of EGR2 during the myelination process is controlled by a myelinating Schwann cell enhancer (MSE) 35 kb downstream of the gene (Ghislain et al, 2002). The MSE is bound by SOX10, POU3F1 and POU3F2 (Ghislain and Charnay, 2006; Reiprich et al, 2010). SOX10 in turn recruits SMARCA4, HDAC1 and HDAC2 to play overlapping but non-redundant roles in activating EGR2 expression (Jacob et al, 2011; Chen et al, 2011; Weider et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
21423191	HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination Chen, Y, Wang, H, Yoon, SO, Xu, X, Hottiger, MO, Svaren, J, Nave, KA, Kim, HA, Olson, EN, Lu, QR	Nat. Neurosci.	2011
21423190	HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells Jacob, C, Christen, CN, Pereira, JA, Somandin, C, Baggiolini, A, Lötscher, P, Ozçelik, M, Tricaud, N, Meijer, D, Yamaguchi, T, Matthias, P, Suter, U	Nat. Neurosci.	2011
18803322	The molecular machinery of myelin gene transcription in Schwann cells Svaren, J, Meijer, D	Glia	2008
22053691	Early growth response 1--a transcription factor in the crossfire of signal transduction cascades Pagel, JI, Deindl, E	Indian J. Biochem. Biophys.	2011
10203854	The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience O'Donovan, KJ, Tourtellotte, WG, Millbrandt, J, Baraban, JM	Trends Neurosci.	1999
22814607	Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination Weider, M, Küspert, M, Bischof, M, Vogl, MR, Hornig, J, Loy, K, Kosian, T, Müller, J, Hillgärtner, S, Tamm, ER, Metzger, D, Wegner, M	Dev. Cell	2012
9858769	Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins Herdegen, T, Leah, JD	Brain Res. Brain Res. Rev.	1998
7935840	Krox-20 controls myelination in the peripheral nervous system Topilko, P, Schneider-Maunoury, S, Levi, G, Baron-Van Evercooren, A, Chennoufi, AB, Seitanidou, T, Babinet, C, Charnay, P	Nature	1994
11782409	Characterisation of cis-acting sequences reveals a biphasic, axon-dependent regulation of Krox20 during Schwann cell development Ghislain, J, Desmarquet-Trin-Dinh, C, Jaegle, M, Meijer, D, Charnay, P, Frain, M	Development	2002
19922439	Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells Reiprich, S, Kriesch, J, Schreiner, S, Wegner, M	J. Neurochem.	2010
16311519	Control of myelination in Schwann cells: a Krox20 cis-regulatory element integrates Oct6, Brn2 and Sox10 activities Ghislain, J, Charnay, P	EMBO Rep.	2006
21326363	Activation and function of immediate-early genes in the nervous system Pérez-Cadahía, B, Drobic, B, Davie, JR	Biochem. Cell Biol.	2011
27220739	Gene regulation in the immediate-early response process Bahrami, S, Drabløs, F	Adv Biol Regul	2016