Reactome | NAB2 [nucleoplasm]

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-NUL-9616359] Cdk5r1 gene:Egr1:NAB2 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9613463] ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-NUL-9616362] NAB2 binds Egr1 at the Cdk5r1 promoter - Homo sapiens [Reaction:R-HSA-9616367] NAB2 binds EGR1 to repress CDK5R1 gene expression - Homo sapiens [Reaction:R-HSA-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression - Homo sapiens [Reaction:R-HSA-9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions - Homo sapiens
created	[InstanceEdit:9612176] Rothfels, Karen, 2018-06-26
dbId	9612177
displayName	NAB2 [nucleoplasm]
endCoordinate	525
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-9612177] Nab2 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-9612177] Nab2 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-9612177] NAB2 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-9612177] NAB2 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-9612177] NAB2 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-9612177] nab2 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-GGA-9612177] NAB2 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-9612177] nab [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-9612177] mab-10 [nucleoplasm] - Caenorhabditis elegans
maxDepth	1
memberOf	[DefinedSet:R-HSA-9612546] NAB1,2 [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:9851828] D'Eustachio, Peter, 2023-10-31
name	NAB2 NGFI-A-binding protein 2 NAB2_HUMAN
producedByEvent	[BlackBoxEvent:R-HSA-9612493] EGR-dependent NAB2 gene expression - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q15742] UniProt:Q15742 NAB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9612177
startCoordinate	1
updateTrackers	[UpdateTracker:9906518] Update Tracker - [EntityWithAccessionedSequence:9612177] NAB2 [nucleoplasm] - v87:[modifyEndCoordinate]

(updatedInstance)	[UpdateTracker:9906518] Update Tracker - [EntityWithAccessionedSequence:9612177] NAB2 [nucleoplasm] - v87:[modifyEndCoordinate]
(hasComponent)	[Complex:R-NUL-9616359] Cdk5r1 gene:Egr1:NAB2 [nucleoplasm] [Complex:R-HSA-9613463] ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] [Complex:R-HSA-9616364] CDK5R1 gene:EGR1:NAB2 [nucleoplasm] [Complex:R-HSA-9613187] RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm]
(input)	[Reaction:R-NUL-9616362] NAB2 binds Egr1 at the Cdk5r1 promoter [Reaction:R-HSA-9616367] NAB2 binds EGR1 to repress CDK5R1 gene expression [Reaction:R-HSA-9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions [Reaction:R-HSA-9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression
(activeUnit)	[NegativeGeneExpressionRegulation:9613192] Negative gene expression regulation by 'RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm]' [NegativeRegulation:9613473] Negative regulation by 'ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm]' [NegativeGeneExpressionRegulation:9616366] Negative gene expression regulation by 'CDK5R1 gene:EGR1:NAB2 [nucleoplasm]' [NegativeGeneExpressionRegulation:9613191] Negative gene expression regulation by 'EGR1 gene:EGR1:NAB1,NAB2 [nucleoplasm]' [PositiveGeneExpressionRegulation:9618736] Positive gene expression regulation by 'GJB11 gene:SOX10:EGR2:NAB1,2 [nucleoplasm]'
(output)	[BlackBoxEvent:R-HSA-9612493] EGR-dependent NAB2 gene expression
(hasMember)	[DefinedSet:R-HSA-9612546] NAB1,2 [nucleoplasm]

NAB2 [nucleoplasm] Show undefined attributes

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