Reactome | NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression

NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression

Stable Identifier

R-HSA-9613213

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)

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NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression

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NAB2 is recruited to EGR2 to the RRAD promoter through interaction with the NCD1 (NAB conserved domain 1) (Svaren et al, 1996; Svaren et al, 1998). NAB2 in turn recruits the CHD4 subunit of the NURD chromatin remodelling complex through its CID (CHD4-interacting domain) and in this manner, represses transcription from the RRAD promoter (Srinivasan et al, 2006; Mager et al, 2008). In addition to roles in cellular proliferation and cardiac function, RRAD protein is known to contribute to RHO signaling, which promotes Schwann cell migration and myelination (Zhu et al, 1999; Wang et al, 2010; Chang et al, 2007, Ward et al, 2002; Yamauchi et al, 2004; Melendez-Vasquez et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
9418898	Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain Swirnoff, AH, Apel, ED, Svaren, J, Sevetson, BR, Zimonjic, DB, Popescu, NC, Milbrandt, J	Mol. Cell. Biol.	1998
16574654	NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex Srinivasan, R, Mager, GM, Ward, RM, Mayer, J, Svaren, J	J. Biol. Chem.	2006
8668170	NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli Svaren, J, Sevetson, BR, Apel, ED, Zimonjic, DB, Popescu, NC, Milbrandt, J	Mol. Cell. Biol.	1996
15102911	Rho kinase regulates schwann cell myelination and formation of associated axonal domains Melendez-Vasquez, CV, Einheber, S, Salzer, JL	J. Neurosci.	2004
11956230	The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway Ward, Y, Yap, SF, Ravichandran, V, Matsumura, F, Ito, M, Spinelli, B, Kelly, K	J. Cell Biol.	2002
18456662	Active gene repression by the Egr2.NAB complex during peripheral nerve myelination Mager, GM, Ward, RM, Srinivasan, R, Jang, SW, Wrabetz, L, Svaren, J	J. Biol. Chem.	2008
10611312	Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation Zhu, J, Tseng, YH, Kantor, JD, Rhodes, CJ, Zetter, BR, Moyers, JS, Kahn, CR	Proc. Natl. Acad. Sci. U.S.A.	1999
19926875	Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart Wang, G, Zhu, X, Xie, W, Han, P, Li, K, Sun, Z, Wang, Y, Chen, C, Song, R, Cao, C, Zhang, J, Wu, C, Liu, J, Cheng, H	Circ. Res.	2010
15161978	Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases Yamauchi, J, Chan, JR, Shooter, EM	Proc. Natl. Acad. Sci. U.S.A.	2004
18056528	Rad GTPase deficiency leads to cardiac hypertrophy Chang, L, Zhang, J, Tseng, YH, Xie, CQ, Ilany, J, Brüning, JC, Sun, Z, Zhu, X, Cui, T, Youker, KA, Yang, Q, Day, SM, Kahn, CR, Chen, YE	Circulation	2007