NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression

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R-HSA-9613213
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Homo sapiens
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NAB2 is recruited to EGR2 to the RRAD promoter through interaction with the NCD1 (NAB conserved domain 1) (Svaren et al, 1996; Svaren et al, 1998). NAB2 in turn recruits the CHD4 subunit of the NURD chromatin remodelling complex through its CID (CHD4-interacting domain) and in this manner, represses transcription from the RRAD promoter (Srinivasan et al, 2006; Mager et al, 2008). In addition to roles in cellular proliferation and cardiac function, RRAD protein is known to contribute to RHO signaling, which promotes Schwann cell migration and myelination (Zhu et al, 1999; Wang et al, 2010; Chang et al, 2007, Ward et al, 2002; Yamauchi et al, 2004; Melendez-Vasquez et al, 2004).

Literature References
PubMed ID Title Journal Year
9418898 Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain

Swirnoff, AH, Popescu, NC, Zimonjic, DB, Milbrandt, J, Apel, ED, Sevetson, BR, Svaren, J

Mol. Cell. Biol. 1998
16574654 NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex

Mager, GM, Ward, RM, Mayer, J, Svaren, J, Srinivasan, R

J. Biol. Chem. 2006
8668170 NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

Popescu, NC, Zimonjic, DB, Milbrandt, J, Apel, ED, Sevetson, BR, Svaren, J

Mol. Cell. Biol. 1996
15102911 Rho kinase regulates schwann cell myelination and formation of associated axonal domains

Salzer, JL, Einheber, S, Melendez-Vasquez, CV

J. Neurosci. 2004
11956230 The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

Spinelli, B, Ravichandran, V, Yap, SF, Ward, Y, Matsumura, F, Ito, M, Kelly, K

J. Cell Biol. 2002
18456662 Active gene repression by the Egr2.NAB complex during peripheral nerve myelination

Wrabetz, L, Mager, GM, Ward, RM, Svaren, J, Jang, SW, Srinivasan, R

J. Biol. Chem. 2008
10611312 Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation

Kahn, CR, Zhu, J, Moyers, JS, Tseng, YH, Kantor, JD, Zetter, BR, Rhodes, CJ

Proc. Natl. Acad. Sci. U.S.A. 1999
19926875 Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart

Chen, C, Cheng, H, Wu, C, Wang, G, Song, R, Han, P, Cao, C, Xie, W, Li, K, Sun, Z, Zhu, X, Liu, J, Zhang, J, Wang, Y

Circ. Res. 2010
15161978 Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases

Shooter, EM, Chan, JR, Yamauchi, J

Proc. Natl. Acad. Sci. U.S.A. 2004
18056528 Rad GTPase deficiency leads to cardiac hypertrophy

Kahn, CR, Tseng, YH, Chang, L, Chen, YE, Ilany, J, Yang, Q, Cui, T, Sun, Z, BrĂ¼ning, JC, Day, SM, Zhu, X, Xie, CQ, Youker, KA, Zhang, J

Circulation 2007
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