Reactome | ERK1/2/5 activate RSK1/2/3

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ERK1/2/5 activate RSK1/2/3 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:199864] protein serine/threonine kinase activity of p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:198764] 2007-07-10 08:01:57
dbId	198746
displayName	ERK1/2/5 activate RSK1/2/3
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK - Homo sapiens [Pathway:R-HSA-198753] ERK/MAPK targets - Homo sapiens [Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Homo sapiens
followingEvent	[Reaction:R-HSA-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Homo sapiens [Reaction:R-HSA-3857328] RPS6KA1/2/3 phosphorylates CEBPB on S321 - Homo sapiens
input	6 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [DefinedSet:R-HSA-199858] Ribosomal protein S6 kinase [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199940] The MAP kinase ERK5 binds to and phosphorylates p90 RSK [LiteratureReference:444269] Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ERK1/2/5 activate RSK1/2/3
orthologousEvent	[Reaction:R-SCE-198746] ERK1/2/5 activate RSK1/2/3 - Saccharomyces cerevisiae [Reaction:R-SPO-198746] ERK1/2/5 activate RSK1/2/3 - Schizosaccharomyces pombe [Reaction:R-DDI-198746] ERK1/2/5 activate RSK1/2/3 - Dictyostelium discoideum [Reaction:R-CEL-198746] ERK1/2/5 activate RSK1/2/3 - Caenorhabditis elegans [Reaction:R-DME-198746] ERK1/2/5 activate RSK1/2/3 - Drosophila melanogaster [Reaction:R-GGA-198746] ERK1/2/5 activate RSK1/2/3 - Gallus gallus [Reaction:R-XTR-198746] ERK1/2/5 activate RSK1/2/3 - Xenopus tropicalis [Reaction:R-DRE-198746] ERK1/2/5 activate RSK1/2/3 - Danio rerio [Reaction:R-SSC-198746] ERK1/2/5 activate RSK1/2/3 - Sus scrofa [Reaction:R-BTA-198746] ERK1/2/5 activate RSK1/2/3 - Bos taurus [Reaction:R-CFA-198746] ERK1/2/5 activate RSK1/2/3 - Canis familiaris [Reaction:R-RNO-198746] ERK1/2/5 activate RSK1/2/3 - Rattus norvegicus [Reaction:R-MMU-198746] ERK1/2/5 activate RSK1/2/3 - Mus musculus
output	6 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [DefinedSet:R-HSA-199849] Phospho-Ribosomal protein S6 kinase [nucleoplasm]
precedingEvent	[Reaction:R-HSA-198714] ERK5 translocates to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-9610166] p-T,Y MAPK dimers translocate to nucleus - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-198746
summation	[Summation:199918] The p90 ribosomal S6 kinases (RSK1-4) comprise a family of s...
updateTrackers	[UpdateTracker:9778945] Update Tracker - [Reaction:198746] ERK1/2/5 activate RSK1/2/3 - v67:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9778945] Update Tracker - [Reaction:198746] ERK1/2/5 activate RSK1/2/3 - v67:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK [Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) [Pathway:R-HSA-198753] ERK/MAPK targets
(precedingEvent)	[Reaction:R-HSA-199895] RSK1/2/3 phosphorylates CREB at Serine 119 [Reaction:R-HSA-3857328] RPS6KA1/2/3 phosphorylates CEBPB on S321

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