p-T,Y MAPK dimers translocate to nucleus

Stable Identifier
R-HSA-9610166
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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p-T,Y MAPK dimers translocate to nucleus
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After phosphorylation by MAP2Ks, a proportion of activated MAPK dimers translocate into the nucleus where it activates nuclear targets involved in neuronal differentiation (Mullenbrock et al, 2011; Adams et al, 2017; reviewed in Santiago and Bashaw, 2014). Although dimerization of MAPKs was originally thought to be critcal for nuclear translocation, a number of studies have now challenged the physiological relevance of MAPK dimerization, and this remains an area of uncertainty (reviewed in Casar et al, 2009; Roskoski, 2012).
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Orthologous Events
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p-T,Y MAPK dimers translocate to nucleus (Drosophila melanogaster)
p-T,Y MAPK dimers translocate to nucleus (Gallus gallus)
p-T,Y MAPK dimers translocate to nucleus (Mus musculus)
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p-T,Y MAPK dimers translocate to nucleus (Sus scrofa)
p-T,Y MAPK dimers translocate to nucleus (Xenopus tropicalis)
Authored
Rothfels, K  (2018-06-05)
Reviewed
Roskoski, R Jr  (2015-04-29)
Created
Rothfels, K  (2018-06-05)
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