Reactome | p-T,Y MAPK dimers translocate to nucleus

p-T,Y MAPK dimers translocate to nucleus

Stable Identifier

R-HSA-9610166

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        Frs2-mediated activation (Homo sapiens)
        
        p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)

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p-T,Y MAPK dimers translocate to nucleus

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After phosphorylation by MAP2Ks, a proportion of activated MAPK dimers translocate into the nucleus where it activates nuclear targets involved in neuronal differentiation (Mullenbrock et al, 2011; Adams et al, 2017; reviewed in Santiago and Bashaw, 2014). Although dimerization of MAPKs was originally thought to be critcal for nuclear translocation, a number of studies have now challenged the physiological relevance of MAPK dimerization, and this remains an area of uncertainty (reviewed in Casar et al, 2009; Roskoski, 2012).

Literature References

PubMed ID	Title	Journal	Year
19279408	ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task Casar, B, Pinto, A, Crespo, P	Cell Cycle	2009
28076410	Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells Adams, KW, Kletsov, S, Lamm, RJ, Elman, JS, Mullenbrock, S, Cooper, GM	PLoS ONE	2017
25468936	Transcription factors and effectors that regulate neuronal morphology Santiago, C, Bashaw, GJ	Development	2014
22065583	Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation Mullenbrock, S, Shah, J, Cooper, GM	J. Biol. Chem.	2011
22569528	ERK1/2 MAP kinases: structure, function, and regulation Roskoski, R Jr	Pharmacol. Res.	2012