After phosphorylation by MAP2Ks, a proportion of activated MAPK dimers translocate into the nucleus where it activates nuclear targets involved in neuronal differentiation (Mullenbrock et al, 2011; Adams et al, 2017; reviewed in Santiago and Bashaw, 2014). Although dimerization of MAPKs was originally thought to be critcal for nuclear translocation, a number of studies have now challenged the physiological relevance of MAPK dimerization, and this remains an area of uncertainty (reviewed in Casar et al, 2009; Roskoski, 2012).
Casar, B, Pinto, A, Crespo, P
Adams, KW, Kletsov, S, Lamm, RJ, Elman, JS, Mullenbrock, S, Cooper, GM
Santiago, C, Bashaw, GJ
Mullenbrock, S, Shah, J, Cooper, GM
Roskoski, R Jr
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