Reactome | p-T,Y MAPK dimers [cytosol]

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p-T,Y MAPK dimers [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:1268259] MAP kinase activity of p-T,Y MAPK dimers [cytosol] [CatalystActivity:4793923] protein serine/threonine kinase activity of p-T,Y MAPK dimers [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9635740] PTPN7:p-T,Y-MAPK dimers [cytosol] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-9610166] p-T,Y MAPK dimers translocate to nucleus - Homo sapiens [Reaction:R-HSA-9635743] PTPN7 binds p-T,Y-MAPK - Homo sapiens [Reaction:R-HSA-6811472] IER3 recruits MAPKs to PP2A-B56-beta,gamma - Homo sapiens
created	[InstanceEdit:1268260] Rothfels, K, 2011-05-09
dbId	1268261
displayName	p-T,Y MAPK dimers [cytosol]
hasMember	[Complex:R-HSA-109844] p-T202, Y204 MAPK3 dimer [cytosol] - Homo sapiens [Complex:R-HSA-109855] p-T185,Y187 MAPK1 dimer [cytosol] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-1268261] p-T,Y MAPK dimers [cytosol] - Mus musculus [DefinedSet:R-RNO-1268261] p-T,Y MAPK dimers [cytosol] - Rattus norvegicus [DefinedSet:R-CFA-1268261] p-T,Y MAPK dimers [cytosol] - Canis familiaris [DefinedSet:R-BTA-1268261] p-T,Y MAPK dimers [cytosol] - Bos taurus [DefinedSet:R-SSC-1268261] p-T,Y MAPK dimers [cytosol] - Sus scrofa [DefinedSet:R-DRE-1268261] p-T,Y MAPK dimers [cytosol] - Danio rerio [Complex:R-XTR-109855] p-T185,Y187 MAPK1 dimer [cytosol] - Xenopus tropicalis [Complex:R-GGA-109855] p-T185,Y187 MAPK1 dimer [cytosol] - Gallus gallus [DefinedSet:R-DME-1268261] p-T,Y MAPK dimers [cytosol] - Drosophila melanogaster [DefinedSet:R-CEL-1268261] p-T,Y MAPK dimers [cytosol] - Caenorhabditis elegans [DefinedSet:R-DDI-1268261] p-T,Y MAPK dimers [cytosol] - Dictyostelium discoideum
isRequired	[Requirement:R-HSA-1295627] Requirement by 'p-T,Y MAPK dimers [cytosol]'
maxDepth	3
memberOf	[DefinedSet:R-HSA-5674340] p-T,Y MAPK monomers and dimers [cytosol] - Homo sapiens
modified	[InstanceEdit:5674418] Rothfels, Karen, 2015-02-12
name	p-T,Y MAPK dimers p-ERK dimer
negativelyRegulates	[NegativeRegulation:9732720] Negative regulation by 'p-T,Y MAPK dimers [cytosol]'
positivelyRegulates	[Requirement:R-HSA-1295627] Requirement by 'p-T,Y MAPK dimers [cytosol]' [PositiveRegulation:R-HSA-8944062] Positive regulation by 'p-T,Y MAPK dimers [cytosol]'
producedByEvent	[BlackBoxEvent:R-HSA-9732753] JAK1-activated RAF1 phosphorylates MAPKs - Homo sapiens [Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens [Reaction:R-HSA-6811454] MAPKs phosphorylate PP2A - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1268261
updateTrackers	[UpdateTracker:9892089] Update Tracker - [DefinedSet:1268261] p-T,Y MAPK dimers [cytosol] - v52:[addName, updateContainedMemberOrCandidate]

Referrals

(updatedInstance)	[UpdateTracker:9892089] Update Tracker - [DefinedSet:1268261] p-T,Y MAPK dimers [cytosol] - v52:[addName, updateContainedMemberOrCandidate]
(regulator)	[Requirement:R-HSA-1295627] Requirement by 'p-T,Y MAPK dimers [cytosol]' [NegativeRegulation:9732720] Negative regulation by 'p-T,Y MAPK dimers [cytosol]' [PositiveRegulation:R-HSA-8944062] Positive regulation by 'p-T,Y MAPK dimers [cytosol]'
(physicalEntity)	[CatalystActivity:1268259] MAP kinase activity of p-T,Y MAPK dimers [cytosol] [CatalystActivity:4793923] protein serine/threonine kinase activity of p-T,Y MAPK dimers [cytosol]
(input)	[Reaction:R-HSA-9635743] PTPN7 binds p-T,Y-MAPK [Reaction:R-HSA-6811472] IER3 recruits MAPKs to PP2A-B56-beta,gamma [BlackBoxEvent:R-HSA-9610166] p-T,Y MAPK dimers translocate to nucleus
(hasComponent)	[Complex:R-HSA-9635740] PTPN7:p-T,Y-MAPK dimers [cytosol] [Complex:R-HSA-6811477] PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]
(output)	[Reaction:R-HSA-6811454] MAPKs phosphorylate PP2A [BlackBoxEvent:R-HSA-9732753] JAK1-activated RAF1 phosphorylates MAPKs [Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize
(activeUnit)	[CatalystActivity:6811498] protein serine/threonine kinase activity of PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]
(hasMember)	[DefinedSet:R-HSA-5674340] p-T,Y MAPK monomers and dimers [cytosol]

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