Reactome | MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF

MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF

Stable Identifier

R-HSA-9610156

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        Frs2-mediated activation (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)

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MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF

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Activated MAP2K1 and MAP2K2 dimers phosphorylate MAPK1 and MAPK3 downstream of NGF stimulation and RAP1 activation at the endosome (Kao et al, 2001; Wu et al, 2001; reviewed in Huang and Reichardt, 2003; Reichardt, 2006).

Literature References

PubMed ID	Title	Journal	Year
11278445	Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells Kao, S, Jaiswal, RK, Kolch, W, Landreth, GE	J Biol Chem	2001
16939974	Neurotrophin-regulated signalling pathways Reichardt, LF	Philos Trans R Soc Lond B Biol Sci	2006
12676795	Trk receptors: roles in neuronal signal transduction Huang, EJ, Reichardt, LF	Annu Rev Biochem	2003
11466412	Nerve growth factor activates persistent Rap1 signaling in endosomes Lai, CF, Mobley, WC	J Neurosci	2001