MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF

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R-HSA-9610156
Type
Reaction
Species
Homo sapiens
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Activated MAP2K1 and MAP2K2 dimers phosphorylate MAPK1 and MAPK3 downstream of NGF stimulation and RAP1 activation at the endosome (Kao et al, 2001; Wu et al, 2001; reviewed in Huang and Reichardt, 2003; Reichardt, 2006).

Literature References
PubMed ID Title Journal Year
11278445 Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

Kao, S, Kolch, W, Landreth, GE, Jaiswal, RK

J Biol Chem 2001
16939974 Neurotrophin-regulated signalling pathways

Reichardt, LF

Philos Trans R Soc Lond B Biol Sci 2006
12676795 Trk receptors: roles in neuronal signal transduction

Reichardt, LF, Huang, EJ

Annu Rev Biochem 2003
11466412 Nerve growth factor activates persistent Rap1 signaling in endosomes

Mobley, WC, Lai, CF

J Neurosci 2001
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Catalyst Activity

protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]

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