Reactome | p-IRF7:p-IRF7 translocates to the nucleus

p-IRF7:p-IRF7 translocates to the nucleus

Stable Identifier

R-HSA-9604487

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

ReviewStatus

5/5

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p-IRF7:p-IRF7 translocates to the nucleus

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p-IRF7 dimers are then transported into the nucleus and assemble with the coactivator CBP/p300 to activate transcription of type I interferons and other target genes.

DExH/D-box helicase 36 (DHX36)-mediated sensing of CpG-A trigger downstream signaling to activation of interferon regulatory transcription factor 7 (IRF7). Knockdown of DHX36 expression by RNA interference in the CpG-A-treated human plasmacytoid dendritic cell line Gen2.2 inhibited nuclear localization of IRF7 (Kim T et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20696886	Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells Kim, T, Pazhoor, S, Bao, M, Zhang, Z, Hanabuchi, S, Facchinetti, V, Bover, L, Plumas, J, Chaperot, L, Qin, J, Liu, YJ	Proc. Natl. Acad. Sci. U.S.A.	2010
11073981	Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain Marié, I, Smith, E, Prakash, A, Levy, DE	Mol Cell Biol	2000
20043992	Structural insights into interferon regulatory factor activation Chen, W, Royer WE, Jr	Cell Signal	2010