p-IRF7:p-IRF7 translocates to the nucleus

Stable Identifier
R-HSA-9604487
Type
Reaction [transition]
Species
Homo sapiens
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p-IRF7 dimers are then transported into the nucleus and assemble with the coactivator CBP/p300 to activate transcription of type I interferons and other target genes.

DExH/D-box helicase 36 (DHX36)-mediated sensing of CpG-A trigger downstream signaling to activation of interferon regulatory transcription factor 7 (IRF7). Knockdown of DHX36 expression by RNA interference in the CpG-A-treated human plasmacytoid dendritic cell line Gen2.2 inhibited nuclear localization of IRF7 (Kim T et al. 2010).

Literature References
PubMed ID Title Journal Year
11073981 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

MariƩ, I, Smith, E, Prakash, A, Levy, DE

Mol Cell Biol 2000
20696886 Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

Kim, T, Pazhoor, S, Bao, M, Zhang, Z, Hanabuchi, S, Facchinetti, V, Bover, L, Plumas, J, Chaperot, L, Qin, J, Liu, YJ

Proc. Natl. Acad. Sci. U.S.A. 2010
20043992 Structural insights into interferon regulatory factor activation

Chen, W, Royer WE, Jr

Cell Signal 2010
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