p-IRF7 dimers are then transported into the nucleus and asse...

created [InstanceEdit:9604488] Shamovsky, Veronica, 2018-04-03
dbId 9604489
displayName p-IRF7 dimers are then transported into the nucleus and asse...
literatureReference
modified [InstanceEdit:9604495] Shamovsky, Veronica, 2018-04-03
schemaClass Summation
text p-IRF7 dimers are then transported into the nucleus and assemble with the coactivator CBP/p300 to activate transcription of type I interferons and other target genes.

DExH/D-box helicase 36 (DHX36)-mediated sensing of CpG-A trigger downstream signaling to activation of interferon regulatory transcription factor 7 (IRF7). Knockdown of DHX36 expression by RNA interference in the CpG-A-treated human plasmacytoid dendritic cell line Gen2.2 inhibited nuclear localization of IRF7 (Kim T et al. 2010).

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