Reactome | DEx/H-box helicases activate type I IFN and inflammatory cytokines production

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DEx/H-box helicases activate type I IFN and inflammatory cytokines production Show undefined attributes

authored	[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
created	[InstanceEdit:3134956] Shamovsky, V, 2013-02-13
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	3134963
displayName	DEx/H-box helicases activate type I IFN and inflammatory cytokines production
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3134962] DHX36 binds DNA - Homo sapiens [Reaction:R-HSA-3134954] DHX9 binds DNA - Homo sapiens [Reaction:R-HSA-3134953] DHX36 or DHX9 binds MyD88 - Homo sapiens [Reaction:R-HSA-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-9604480] NFkB complex translocates from the cytosol to the nucleus - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:3134870] Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	DEx/H-box helicases activate type I IFN and inflammatory cytokines production
orthologousEvent	[Pathway:R-MMU-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Mus musculus [Pathway:R-PFA-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Plasmodium falciparum [Pathway:R-DDI-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Dictyostelium discoideum [Pathway:R-CEL-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Caenorhabditis elegans [Pathway:R-DME-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Drosophila melanogaster [Pathway:R-GGA-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Gallus gallus [Pathway:R-XTR-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Xenopus tropicalis [Pathway:R-DRE-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Danio rerio [Pathway:R-SSC-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Sus scrofa [Pathway:R-BTA-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Bos taurus [Pathway:R-CFA-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Canis familiaris [Pathway:R-RNO-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Rattus norvegicus
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3134963
summation	[Summation:3134959] DHX36 and DHX9 are aspartate-glutamate-any amino acid aspart...
updateTrackers	[UpdateTracker:9779651] Update Tracker - [Pathway:3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - v65:[add_removeHasEvent] [UpdateTracker:9775074] Update Tracker - [Pathway:3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - v80:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9779651] Update Tracker - [Pathway:3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - v65:[add_removeHasEvent] [UpdateTracker:9775074] Update Tracker - [Pathway:3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - v80:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA

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