Reactome | Pellino binds hp-IRAK1:TRAF6

Schema > Reaction > Entries

Pellino binds hp-IRAK1:TRAF6 Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
dbId	937044
displayName	Pellino binds hp-IRAK1:TRAF6
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-937039] IRAK1 recruits IKK complex - Homo sapiens
followingEvent	[Reaction:R-HSA-937034] IRAK1 phosphorylates Pellino - Homo sapiens
input	[CandidateSet:R-HSA-450819] p-Pellino-1,2,(3) [cytosol] [Complex:R-HSA-937036] TRAF6:hp-IRAK1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451409] Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases [LiteratureReference:451412] The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Pellino binds hp-IRAK1:TRAF6
orthologousEvent	[Reaction:R-DME-937044] Pellino binds hp-IRAK1:TRAF6 - Drosophila melanogaster [Reaction:R-DRE-937044] Pellino binds hp-IRAK1:TRAF6 - Danio rerio [Reaction:R-SSC-937044] Pellino binds hp-IRAK1:TRAF6 - Sus scrofa [Reaction:R-BTA-937044] Pellino binds hp-IRAK1:TRAF6 - Bos taurus [Reaction:R-CFA-937044] Pellino binds hp-IRAK1:TRAF6 - Canis familiaris [Reaction:R-RNO-937044] Pellino binds hp-IRAK1:TRAF6 - Rattus norvegicus [Reaction:R-MMU-937044] Pellino binds hp-IRAK1:TRAF6 - Mus musculus
output	[Complex:R-HSA-937020] TRAF6:hp-IRAK1:Pellino [plasma membrane]
precedingEvent	[Reaction:R-HSA-166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - Homo sapiens [Reaction:R-HSA-975879] Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-937044
summation	[Summation:940417] Pellino isoforms -1, 2 and 3 have been shown to interact wit...
updateTrackers	[UpdateTracker:9788251] Update Tracker - [Reaction:937044] Pellino binds hp-IRAK1:TRAF6 - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788251] Update Tracker - [Reaction:937044] Pellino binds hp-IRAK1:TRAF6 - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-937039] IRAK1 recruits IKK complex
(precedingEvent)	[Reaction:R-HSA-937034] IRAK1 phosphorylates Pellino