Reactome | IRAK1 recruits IKK complex

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IRAK1 recruits IKK complex Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	937039
displayName	IRAK1 recruits IKK complex
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens [Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161528] positive regulation of canonical NF-kappaB signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-937044] Pellino binds hp-IRAK1:TRAF6 - Homo sapiens [Reaction:R-HSA-937034] IRAK1 phosphorylates Pellino - Homo sapiens [Reaction:R-HSA-937050] Pellino ubiquitinates hp-IRAK1 - Homo sapiens [Reaction:R-HSA-937032] NEMO subunit of IKK complex binds to activated IRAK1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2012-12-31
literatureReference	[LiteratureReference:507721] Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3 [LiteratureReference:975459] IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation [LiteratureReference:970055] IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression [LiteratureReference:507718] Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappaB activation requires cytosolic and nuclear activity [LiteratureReference:975472] Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction [LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation [LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:975484] The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	IRAK1 recruits IKK complex
orthologousEvent	[Pathway:R-DME-937039] IRAK1 recruits IKK complex - Drosophila melanogaster [Pathway:R-DRE-937039] IRAK1 recruits IKK complex - Danio rerio [Pathway:R-SSC-937039] IRAK1 recruits IKK complex - Sus scrofa [Pathway:R-BTA-937039] IRAK1 recruits IKK complex - Bos taurus [Pathway:R-CFA-937039] IRAK1 recruits IKK complex - Canis familiaris [Pathway:R-RNO-937039] IRAK1 recruits IKK complex - Rattus norvegicus [Pathway:R-MMU-937039] IRAK1 recruits IKK complex - Mus musculus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-937039
summation	[Summation:970054] The role of IRAK1 kinase activity in the activation of NF-ka...
updateTrackers	[UpdateTracker:9788182] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v43:[modifyText, updateContainedRLE] [UpdateTracker:9789678] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v37:[updateContainedRLE] [UpdateTracker:9789294] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v38:[addLiteratureReference, modifyText] [UpdateTracker:9788439] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v42:[modifyText, updateContainedRLE]

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(updatedInstance)

[UpdateTracker:9788182] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v43:[modifyText, updateContainedRLE]
[UpdateTracker:9789678] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v37:[updateContainedRLE]
[UpdateTracker:9789294] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9788439] Update Tracker - [Pathway:937039] IRAK1 recruits IKK complex - v42:[modifyText, updateContainedRLE]

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