Reactome | IRAK1 phosphorylates Pellino

Schema > Reaction > Entries

IRAK1 phosphorylates Pellino Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
catalystActivity	[CatalystActivity:937015] protein kinase activity of TRAF6:hp-IRAK1:Pellino [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
dbId	937034
displayName	IRAK1 phosphorylates Pellino
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-937039] IRAK1 recruits IKK complex - Homo sapiens
followingEvent	[Reaction:R-HSA-937050] Pellino ubiquitinates hp-IRAK1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-937020] TRAF6:hp-IRAK1:Pellino [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450692] The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 [LiteratureReference:450812] Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4 [LiteratureReference:450816] Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	IRAK1 phosphorylates Pellino
orthologousEvent	[Reaction:R-DME-937034] IRAK1 phosphorylates Pellino - Drosophila melanogaster [Reaction:R-DRE-937034] IRAK1 phosphorylates Pellino - Danio rerio [Reaction:R-SSC-937034] IRAK1 phosphorylates Pellino - Sus scrofa [Reaction:R-BTA-937034] IRAK1 phosphorylates Pellino - Bos taurus [Reaction:R-CFA-937034] IRAK1 phosphorylates Pellino - Canis familiaris [Reaction:R-RNO-937034] IRAK1 phosphorylates Pellino - Rattus norvegicus [Reaction:R-MMU-937034] IRAK1 phosphorylates Pellino - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-937040] p-Pellino:hp-IRAK1:TRAF6 [plasma membrane]
precedingEvent	[Reaction:R-HSA-937044] Pellino binds hp-IRAK1:TRAF6 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-937034
summation	[Summation:940396] Both IRAK1 and IRAK4 were shown to phosphorylate Pellino iso...
updateTrackers	[UpdateTracker:9788361] Update Tracker - [Reaction:937034] IRAK1 phosphorylates Pellino - v42:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788361] Update Tracker - [Reaction:937034] IRAK1 phosphorylates Pellino - v42:[modifyText]
(precedingEvent)	[Reaction:R-HSA-937050] Pellino ubiquitinates hp-IRAK1
(hasEvent)	[Pathway:R-HSA-937039] IRAK1 recruits IKK complex