Reactome | TRAF6:hp-IRAK1 [plasma membrane]

Schema > Complex > Entries

TRAF6:hp-IRAK1 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-937020] TRAF6:hp-IRAK1:Pellino [plasma membrane] - Homo sapiens [Complex:R-HSA-937040] p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-937044] Pellino binds hp-IRAK1:TRAF6 - Homo sapiens
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
dbId	937036
displayName	TRAF6:hp-IRAK1 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-937011] p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-936955] TRAF6 [plasma membrane]
inDisease	false
inferredTo	[Complex:R-MMU-937036] TRAF6:hp-IRAK1 [plasma membrane] - Mus musculus [Complex:R-RNO-937036] TRAF6:hp-IRAK1 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-937036] TRAF6:hp-IRAK1 [plasma membrane] - Canis familiaris [Complex:R-BTA-937036] TRAF6:hp-IRAK1 [plasma membrane] - Bos taurus [Complex:R-SSC-937036] TRAF6:hp-IRAK1 [plasma membrane] - Sus scrofa [Complex:R-DRE-937036] TRAF6:hp-IRAK1 [plasma membrane] - Danio rerio [Complex:R-DME-937036] TRAF6:hp-IRAK1 [plasma membrane] - Drosophila melanogaster [Complex:R-DDI-937036] TRAF6:hp-IRAK1 [plasma membrane] - Dictyostelium discoideum
isChimeric	false
literatureReference	[LiteratureReference:2428848] IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B [LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:169927] Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
maxDepth	2
memberOf	[DefinedSet:R-HSA-937058] hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane] - Homo sapiens
modified	[InstanceEdit:2428906] Shamovsky, V, 2012-08-08
name	TRAF6:hp-IRAK1
producedByEvent	[Reaction:R-HSA-166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - Homo sapiens [Reaction:R-HSA-166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - Homo sapiens [Reaction:R-HSA-166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - Homo sapiens [Reaction:R-HSA-166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-937036
summation	[Summation:2428857] The listed studies describe an activation of IRAK-TRAF6-TAK1...
updateTrackers	[UpdateTracker:9873247] Update Tracker - [Complex:937036] TRAF6:hp-IRAK1 [plasma membrane] - v42:[addLiteratureReference, addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9873247] Update Tracker - [Complex:937036] TRAF6:hp-IRAK1 [plasma membrane] - v42:[addLiteratureReference, addSummation]
(input)	[Reaction:R-HSA-937044] Pellino binds hp-IRAK1:TRAF6
(hasComponent)	[Complex:R-HSA-937040] p-Pellino:hp-IRAK1:TRAF6 [plasma membrane] [Complex:R-HSA-937020] TRAF6:hp-IRAK1:Pellino [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-937058] hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane]
(output)	[Reaction:R-HSA-166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex

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