Pellino binds hp-IRAK1:TRAF6

Stable Identifier
R-HSA-937044
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pellino binds hp-IRAK1:TRAF6
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Pellino isoforms -1, 2 and 3 have been shown to interact with IRAK1 and IRAK4 (Jiang et al. 2003, Strellow et al. 2003, Butler et al. 2005, 2007). It has been also reported that Pellino-1 forms a complex with TRAF6, but not TAK1 or IL1R (Jiang et al. 2003), suggesting that Pellino-1 function as intermediate complex with IRAK1 in the propagation of signal from the activated receptor to activation of TAK1.

All Pellino isoforms function as E3 ubiquitin ligases in conjunction with several different E2-conjugating enzymes - Ubc13-Uev1a, UbcH4, or UbcH5a/5b.(Schauvliege R et al. 2006, Butler MP et al. 2007, Ordureau A et al. 2008). Their C-terminus contains a RING-like domain which is responsible for IL1-induced Lys63-linked polyubiquitination of IRAK1 in vitro.

Literature References
PubMed ID Title Journal Year
16884718 Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

Janssens, S, Schauvliege, R, Beyaert, R

FEBS Lett 2006
19022706 The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

Moynagh, PN

Trends Immunol 2009
Participants
Input
Output
Participates
as an event of
Orthologous Events
Pellino binds hp-IRAK1:TRAF6 (Bos taurus)
Pellino binds hp-IRAK1:TRAF6 (Canis familiaris)
Pellino binds hp-IRAK1:TRAF6 (Drosophila melanogaster)
Pellino binds hp-IRAK1:TRAF6 (Mus musculus)
Pellino binds hp-IRAK1:TRAF6 (Rattus norvegicus)
Pellino binds hp-IRAK1:TRAF6 (Sus scrofa)
Authored
Shamovsky, V  (2010-06-01)
Reviewed
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Created
Shamovsky, V  (2010-08-25)
Cite Us!