IRAK1 phosphorylates Pellino

Stable Identifier
R-HSA-937034
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Both IRAK1 and IRAK4 were shown to phosphorylate Pellino isoforms in vitro. The phosphorylation of Pellino proteins is a necessary step in enhancing of their E3 ubiquitin ligase activity. It remains unclear whether IRAK1(as shown here), IRAK4, or both protein kinases mediate the activation of Pellino isoforms in vivo.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein kinase activity of TRAF6:hp-IRAK1:Pellino [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created