IRAK1 phosphorylates Pellino

Stable Identifier
R-HSA-937034
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IRAK1 phosphorylates Pellino
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Both IRAK1 and IRAK4 were shown to phosphorylate Pellino isoforms in vitro. The phosphorylation of Pellino proteins is a necessary step in enhancing of their E3 ubiquitin ligase activity. It remains unclear whether IRAK1(as shown here), IRAK4, or both protein kinases mediate the activation of Pellino isoforms in vivo.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein kinase activity of TRAF6:hp-IRAK1:Pellino [plasma membrane]

Physical Entity
TRAF6:hp-IRAK1:Pellino [plasma membrane] (Homo sapiens)
Activity
protein kinase activity (GO:0004672)
Orthologous Events
IRAK1 phosphorylates Pellino (Bos taurus)
IRAK1 phosphorylates Pellino (Canis familiaris)
IRAK1 phosphorylates Pellino (Drosophila melanogaster)
IRAK1 phosphorylates Pellino (Mus musculus)
IRAK1 phosphorylates Pellino (Rattus norvegicus)
IRAK1 phosphorylates Pellino (Sus scrofa)
Authored
Shamovsky, V  (2010-06-01)
Reviewed
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Created
Shamovsky, V  (2010-08-25)
Cite Us!