Reactome | IRAK1 phosphorylates Pellino

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IRAK1 phosphorylates Pellino Show undefined attributes

catalystActivity	[CatalystActivity:10590477] protein kinase activity of TRAF6:hp-IRAK1:Pellino [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10590479
displayName	IRAK1 phosphorylates Pellino
eventOf	[Pathway:R-DRE-937039] IRAK1 recruits IKK complex - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-937050] Pellino ubiquitinates hp-IRAK1 - Danio rerio
inferredFrom	[Reaction:R-HSA-937034] IRAK1 phosphorylates Pellino - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DRE-937020] TRAF6:hp-IRAK1:Pellino [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IRAK1 phosphorylates Pellino
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DRE-937020] TRAF6:hp-IRAK1:Pellino [plasma membrane]
precedingEvent	[Reaction:R-DRE-937044] Pellino binds hp-IRAK1:TRAF6 - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-937034
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-937039] IRAK1 recruits IKK complex
(precedingEvent)	[Reaction:R-DRE-937050] Pellino ubiquitinates hp-IRAK1
(inferredTo)	[Reaction:R-HSA-937034] IRAK1 phosphorylates Pellino

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