Reactome | IRAK2 mediated activation of TAK1 complex

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IRAK2 mediated activation of TAK1 complex Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819447] BioModels Database:BIOMD0000000504 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	937042
displayName	IRAK2 mediated activation of TAK1 complex
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens [Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-936963] IRAK2 induces TRAF6 oligomerization - Homo sapiens [BlackBoxEvent:R-HSA-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Homo sapiens [Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Homo sapiens [Reaction:R-HSA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Homo sapiens [Reaction:R-HSA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-03-24
literatureReference	[LiteratureReference:450151] Distinct molecular mechanism for initiating TRAF6 signalling [LiteratureReference:450125] IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination [LiteratureReference:2428843] Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha [LiteratureReference:451555] The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	IRAK2 mediated activation of TAK1 complex
orthologousEvent	[Pathway:R-DDI-937042] IRAK2 mediated activation of TAK1 complex - Dictyostelium discoideum [Pathway:R-DME-937042] IRAK2 mediated activation of TAK1 complex - Drosophila melanogaster [Pathway:R-GGA-937042] IRAK2 mediated activation of TAK1 complex - Gallus gallus [Pathway:R-XTR-937042] IRAK2 mediated activation of TAK1 complex - Xenopus tropicalis [Pathway:R-DRE-937042] IRAK2 mediated activation of TAK1 complex - Danio rerio [Pathway:R-SSC-937042] IRAK2 mediated activation of TAK1 complex - Sus scrofa [Pathway:R-BTA-937042] IRAK2 mediated activation of TAK1 complex - Bos taurus [Pathway:R-CFA-937042] IRAK2 mediated activation of TAK1 complex - Canis familiaris [Pathway:R-RNO-937042] IRAK2 mediated activation of TAK1 complex - Rattus norvegicus [Pathway:R-MMU-937042] IRAK2 mediated activation of TAK1 complex - Mus musculus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-937042
summation	[Summation:936975] Although IRAK-1 was originally thought to be a key mediator ...
updateTrackers	[UpdateTracker:9788278] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v43:[updateContainedRLE] [UpdateTracker:9776449] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v76:[updateContainedRLE] [UpdateTracker:9789118] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v38:[addLiteratureReference, modifyText] [UpdateTracker:9789937] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v36:[updateContainedRLE] [UpdateTracker:9788359] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v42:[addLiteratureReference] [UpdateTracker:9782339] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v59:[updateContainedRLE] [UpdateTracker:9788509] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v41:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9788278] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v43:[updateContainedRLE]
[UpdateTracker:9776449] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v76:[updateContainedRLE]
[UpdateTracker:9789118] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9789937] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v36:[updateContainedRLE]
[UpdateTracker:9788359] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v42:[addLiteratureReference]
[UpdateTracker:9782339] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v59:[updateContainedRLE]
[UpdateTracker:9788509] Update Tracker - [Pathway:937042] IRAK2 mediated activation of TAK1 complex - v41:[updateContainedRLE]

(hasEvent)

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