Reactome | Activated TRAF6:p-IRAK2 interacts with TAK1 complex

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Activated TRAF6:p-IRAK2 interacts with TAK1 complex Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:936971] Shamovsky, V, 2010-08-25
dbId	936960
displayName	Activated TRAF6:p-IRAK2 interacts with TAK1 complex
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex - Homo sapiens
followingEvent	[Reaction:R-HSA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Homo sapiens
input	3 × [Polymer:R-HSA-450152] K63polyUb [cytosol] [Complex:R-HSA-936988] p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] 3 × [Complex:R-HSA-446878] TAK1 complex [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains [LiteratureReference:208287] TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway [LiteratureReference:2586656] Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated TRAF6:p-IRAK2 interacts with TAK1 complex
orthologousEvent	[Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex - Gallus gallus [Reaction:R-GGA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Gallus gallus [Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Sus scrofa [Reaction:R-BTA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Bos taurus [Reaction:R-CFA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Canis familiaris [Reaction:R-RNO-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Rattus norvegicus [Reaction:R-MMU-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Mus musculus
output	[Complex:R-HSA-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - Homo sapiens [Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-936960
summation	[Summation:447018] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
updateTrackers	[UpdateTracker:9788276] Update Tracker - [Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - v43:[addLiteratureReference, modifyText] [UpdateTracker:9776364] Update Tracker - [Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - v76:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788276] Update Tracker - [Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - v43:[addLiteratureReference, modifyText] [UpdateTracker:9776364] Update Tracker - [Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - v76:[modifyText]
(hasEvent)	[Pathway:R-HSA-937042] IRAK2 mediated activation of TAK1 complex
(precedingEvent)	[Reaction:R-HSA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3

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