Reactome | Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3

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Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 Show undefined attributes

catalystActivity	[CatalystActivity:10262494] MAP kinase kinase kinase kinase activity of p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10262496
displayName	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
eventOf	[Pathway:R-CFA-937042] IRAK2 mediated activation of TAK1 complex - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Canis familiaris [Reaction:R-CFA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Canis familiaris
inferredFrom	[Reaction:R-HSA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane]
precedingEvent	[Reaction:R-CFA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-936991
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-937042] IRAK2 mediated activation of TAK1 complex
(precedingEvent)	[Reaction:R-CFA-450346] activated human TAK1 phosphorylates MKK3/MKK6 [Reaction:R-CFA-450337] Activated TAK1 phosphorylates MKK4/MKK7
(inferredTo)	[Reaction:R-HSA-936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3

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