Reactome | Expression of IFN-induced genes

Schema > BlackBoxEvent > Entries

Expression of IFN-induced genes Show undefined attributes

authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1015701] Garapati, P V, 2010-11-15
dbId	1015702
displayName	Expression of IFN-induced genes
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-909733] Interferon alpha/beta signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9909519] IFI44, IFI44L binds FKBP5 - Homo sapiens [Reaction:R-HSA-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Homo sapiens [BlackBoxEvent:R-HSA-9833635] p-PKR dimer localizes to the nucleus - Homo sapiens [Reaction:R-HSA-9833723] PKR forms a dimer - Homo sapiens [Reaction:R-HSA-9947999] FNTA:PGGT1B geranylgeranylates GBP2 - Homo sapiens [Reaction:R-HSA-9954195] FNTA:PGGT1B geranylgeranylates GBP5 - Homo sapiens
input	[DefinedSet:R-HSA-9034125] Type I IFN-regulated genes with ISRE promoter elements [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1015626] Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2 [LiteratureReference:1014316] Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays [LiteratureReference:1015644] Functional classification of interferon-stimulated genes identified using microarrays [LiteratureReference:1015647] Gene structure and function of the 2'-5'-oligoadenylate synthetase family [LiteratureReference:1015650] Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis [LiteratureReference:1015648] Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells [LiteratureReference:1015668] A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis [LiteratureReference:1015669] Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways [LiteratureReference:1015664] Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus [LiteratureReference:1015638] Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease [LiteratureReference:1015642] Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon [LiteratureReference:1031687] Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells [LiteratureReference:1031655] Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts [LiteratureReference:9690049] Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance [LiteratureReference:9690050] Distinct and overlapping genomic profiles and antiviral effects of Interferon-? and -? on HCV-infected and noninfected hepatoma cells [LiteratureReference:9833475] Interferon-associated, dsRNA-dependent enzyme activities in a mutant 3T6 cell engaged in the semiconstitutive synthesis of interferon
maxDepth	1
modified	[InstanceEdit:9835582] Matthews, Lisa, 2023-05-16
name	Expression of IFN-induced genes
output	[EntityWithAccessionedSequence:R-HSA-53939] ADAR [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5624196] BST2 [plasma membrane] [DefinedSet:R-HSA-983117] Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-1031703] EGR1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-168699] EIF2AK2 [cytosol] [EntityWithAccessionedSequence:R-HSA-1015673] GBP2 [cytosol] [EntityWithAccessionedSequence:R-HSA-1015677] IFI27 [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-947492] IFI35 [cytosol] [EntityWithAccessionedSequence:R-HSA-947487] IFI6 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-937341] IFIT1 [cytosol] [EntityWithAccessionedSequence:R-HSA-1015674] IFIT2 [cytosol] [EntityWithAccessionedSequence:R-HSA-947491] IFIT3 [cytosol] [EntityWithAccessionedSequence:R-HSA-9684472] IFIT5 [cytosol] [EntityWithAccessionedSequence:R-HSA-199523] IFITM1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-1015682] IFITM2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-1015688] IFITM3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-1015687] IP6K2 [nucleoplasm] [DefinedSet:R-HSA-1015695] IRF 1-9 [cytosol] [EntityWithAccessionedSequence:R-HSA-936552] ISG15 [cytosol] [EntityWithAccessionedSequence:R-HSA-1015671] ISG20 [nucleoplasm] [DefinedSet:R-HSA-1015693] Mx GTPases [cytosol] [DefinedSet:R-HSA-1015696] OAS proteins [cytosol] [EntityWithAccessionedSequence:R-HSA-174336] PSMB8 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1015684] RNASEL [cytosol] [EntityWithAccessionedSequence:R-HSA-5624199] RSAD2 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-5624198] SAMHD1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1015680] XAF1 [cytosol]
precedingEvent	[Reaction:R-HSA-1015699] ISGF3 binds the ISRE promoter elements in IFN-stimulated genes - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:R-HSA-1031720] Positive regulation by 'ISGF3 bound to ISRE promotor elements [nucleoplasm]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1015702
summation	[Summation:1014322] Around 300 IFN-induced genes have been identified from diffe...
updateTrackers	[UpdateTracker:9835713] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v85:[addLiteratureReference, addOutput] [UpdateTracker:9776999] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v73:[addLiteratureReference, addOutput] [UpdateTracker:9780157] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v64:[addInput] [UpdateTracker:9785708] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v51:[addOutput]

Referrals

(precedingEvent)	[Reaction:R-HSA-9909519] IFI44, IFI44L binds FKBP5 [Reaction:R-HSA-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate [BlackBoxEvent:R-HSA-9833635] p-PKR dimer localizes to the nucleus [Reaction:R-HSA-9833723] PKR forms a dimer [Reaction:R-HSA-9947999] FNTA:PGGT1B geranylgeranylates GBP2 [Reaction:R-HSA-9954195] FNTA:PGGT1B geranylgeranylates GBP5
(hasEvent)	[Pathway:R-HSA-909733] Interferon alpha/beta signaling
(updatedInstance)	[UpdateTracker:9835713] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v85:[addLiteratureReference, addOutput] [UpdateTracker:9776999] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v73:[addLiteratureReference, addOutput] [UpdateTracker:9780157] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v64:[addInput] [UpdateTracker:9785708] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v51:[addOutput]

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