Reactome | TRAF6 mediated NF-kB activation

Schema > Pathway > Entries

compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556481
displayName	TRAF6 mediated NF-kB activation
eventOf	[Pathway:R-SSC-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Sus scrofa [Reaction:R-SSC-168166] NF-kappa-B complex is transported from cytosol to nucleus - Sus scrofa
inferredFrom	[Pathway:R-HSA-933542] TRAF6 mediated NF-kB activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TRAF6 mediated NF-kB activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-933542
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta
(inferredTo)	[Pathway:R-HSA-933542] TRAF6 mediated NF-kB activation

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