Reactome | TRAF6 mediated NF-kB activation

TRAF6 mediated NF-kB activation

Stable Identifier

R-HSA-933542

Type

Pathway

Species

Homo sapiens

Compartment

mitochondrial outer membrane, cytosol

ReviewStatus

5/5

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The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kappaB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I (DDX58)/MDA5 (IFIH1) pathway is largely unknown. According to the study done by Yoshida et al. the DDX58:MAVS pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kappaB and MAP Kinases for optimal induction of type I IFNs.

Literature References

PubMed ID	Title	Journal	Year
18984593	TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway Yoshida, R, Takaesu, G, Yoshida, H, Okamoto, F, Yoshioka, T, Choi, Y, Akira, S, Kawai, T, Yoshimura, A, Kobayashi, T	J Biol Chem	2008