Caspase-8 (CASP8) and caspase-10 (CASP10) are involved in RI...

created [InstanceEdit:933448] Garapati, P V, 2010-08-16
dbId 933441
displayName Caspase-8 (CASP8) and caspase-10 (CASP10) are involved in RI...
modified [InstanceEdit:9927235] Shamovsky, Veronica, 2024-11-05
schemaClass Summation
text Caspase-8 (CASP8) and caspase-10 (CASP10) are involved in RIG-I (DDX58)/MDA5 (IFIH1)-dependent antiviral immune responses. Caspase-8/10 activation contributes to NF-kB activation in response to viral dsRNA.
Caspase-8/10 are synthesized as zymogens (procaspases), containing a large N-terminal prodomain with two death effector domains (DED), and a C-terminal catalytic subunit composed of small and a large domain separated by a smaller linker region. FADD plays a crucial role in the recruitment and activation of procaspase-8/10. The two DED domains of procaspase-8/10 interacts with DED domain of FADD.
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