Recruitment of caspase-8 and -10 to FADD complex

Stable Identifier
R-HSA-933526
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of caspase-8 and -10 to FADD complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caspase-8 (CASP8) and caspase-10 (CASP10) are involved in RIG-I (DDX58)/MDA5 (IFIH1)-dependent antiviral immune responses. Caspase-8/10 activation contributes to NF-kB activation in response to viral dsRNA.
Caspase-8/10 are synthesized as zymogens (procaspases), containing a large N-terminal prodomain with two death effector domains (DED), and a C-terminal catalytic subunit composed of small and a large domain separated by a smaller linker region. FADD plays a crucial role in the recruitment and activation of procaspase-8/10. The two DED domains of procaspase-8/10 interacts with DED domain of FADD.
Literature References
PubMed ID Title Journal Year
16585540 Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

Takahashi, K, Kawai, T, Kumar, H, Sato, S, Yonehara, S, Akira, S

J Immunol 2006
18761323 Non-apoptotic functions of caspase-8

Maelfait, J, Beyaert, R

Biochem Pharmacol 2008
11717445 Caspase-10 is an initiator caspase in death receptor signaling

Wang, J, Chun, HJ, Wong, W, Spencer, DM, Lenardo, MJ

Proc Natl Acad Sci U S A 2001
16618810 Caspases leave the beaten track: caspase-mediated activation of NF-kappaB

Lamkanfi, M, Declercq, W, Vanden Berghe, T, Vandenabeele, P

J Cell Biol 2006
12107169 Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen

Thomas, LR, Stillman, DJ, Thorburn, A

J Biol Chem 2002
12884866 Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

Shikama, Y, Yamada, M, Miyashita, T

Eur J Immunol 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-08-16)
Cite Us!