Recruitment of IRF3,IRF7

Stable Identifier
R-HSA-918232
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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Recruitment of IRF3,IRF7
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IRF3 and IRF7 (IRF3/IRF7) are the two major members of the interferon regulatory factor (IRF) family, involved in modulating the IFN gene expression. However, their roles are different in these processes. In the early phase of viral infection, preexisting IRF-3 is activated and induces expression of IFN beta and IFN alpha4. These early produced IFNs transcriptionally induce IRF-7, and upon viral infection, the induced high-level IRF-7 is activated and transactivates multiple IFN genes, leading to robust production of IFNs in response to viral infection. MAVS (IPS-1) interacts with both IRF3 and IRF7 and recruits them to RIG-1 (DDX58). TBK1/IKKi kinases phosphorylate and activate IRF3/IRF7.
Literature References
PubMed ID Title Journal Year
16153868 VISA is an adapter protein required for virus-triggered IFN-beta signaling

Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB

Mol Cell 2005
12692549 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, KA, McWhirter, SM, Faia, KL, Rowe, DC, Latz, E, Golenbock, DT, Coyle, AJ, Liao, SM, Maniatis, T

Nat Immunol 2003
16846591 Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages

Solis, M, Goubau, D, Romieu-Mourez, R, Genin, P, Civas, A, Hiscott, J

Biochem Pharmacol 2006
Participants
Input
Output
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as an event of
Orthologous Events
Recruitment of IRF to activated TBK1/IKK epsilon (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-08-02)
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