Reactome | STEAP3,STEAP4 reduce Fe3+ to Fe2+

Schema > Reaction > Entries

STEAP3,STEAP4 reduce Fe3+ to Fe2+ Show undefined attributes

catalystActivity	[CatalystActivity:10590165] ferric-chelate reductase (NADPH) activity of STEAP3,STEAP4 [endosome membrane]
category	transition
compartment	[Compartment:171907] endosome lumen [Compartment:74700] endosome membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10590167
displayName	STEAP3,STEAP4 reduce Fe3+ to Fe2+
eventOf	[Pathway:R-DRE-917977] Transferrin endocytosis and recycling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol - Danio rerio
inferredFrom	[Reaction:R-HSA-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Homo sapiens
input	[SimpleEntity:R-ALL-111736] Fe3+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	STEAP3,STEAP4 reduce Fe3+ to Fe2+ 2 Fe(3+) + NADPH => 2 Fe(2+) + H(+) + NADP(+) Reduction of Fe3+ in the endosome
output	[SimpleEntity:R-ALL-917810] Fe2+ [endosome lumen] [SimpleEntity:R-ALL-74722] H+ [endosome lumen] [SimpleEntity:R-ALL-9861421] NADP+ [endosome lumen]
precedingEvent	[Reaction:R-DRE-917835] Fe3+ dissociates from holoTF:TFRC dimer - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-917811
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-917977] Transferrin endocytosis and recycling
(precedingEvent)	[Reaction:R-DRE-917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol
(inferredTo)	[Reaction:R-HSA-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+

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