STEAP3-like proteins reduce Fe3+ to Fe2+

Stable Identifier
R-HSA-917811
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Reduction of Fe3+ in the endosome
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The iron ions that are no longer bound to transferrin are reduced by the metalloreductase STEAP3, an endosomal membrane protein. The electron donor partner of the enzyme is unknown (Ohgami et al, 2005; Ohgami et al, 2006).

Literature References
PubMed ID Title Journal Year
16609065 The Steap proteins are metalloreductases

Ohgami, RS, Campagna, DR, McDonald, A, Fleming, MD

Blood 2006
16227996 Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

Ohgami, RS, Campagna, DR, Greer, EL, Antiochos, B, McDonald, A, Chen, J, Sharp, JJ, Fujiwara, Y, Barker, JE, Fleming, MD

Nat Genet 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor of STEAP3-like proteins [endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created