STEAP3-like proteins reduce Fe3+ to Fe2+

Stable Identifier
R-HSA-917811
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Reduction of Fe3+ in the endosome
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The iron ions that are no longer bound to transferrin are reduced by the metalloreductase STEAP3, an endosomal membrane protein. The electron donor partner of the enzyme is unknown (Ohgami et al, 2005; Ohgami et al, 2006).

Literature References
PubMed ID Title Journal Year
16227996 Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

Fleming, MD, Ohgami, RS, Fujiwara, Y, Chen, J, Antiochos, B, Greer, EL, Campagna, DR, Barker, JE, McDonald, A, Sharp, JJ

Nat Genet 2005
16609065 The Steap proteins are metalloreductases

Fleming, MD, Ohgami, RS, Campagna, DR, McDonald, A

Blood 2006
Participants
Participates
Catalyst Activity

oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor of STEAP3-like proteins [endosome membrane]

Orthologous Events
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