STEAP3,STEAP4 reduce Fe3+ to Fe2+

Stable Identifier
R-HSA-917811
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
2 Fe(3+) + NADPH => 2 Fe(2+) + H(+) + NADP(+), Reduction of Fe3+ in the endosome
ReviewStatus
4/5
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The iron ions that are no longer bound to transferrin are reduced by the metalloreductases STEAP3 and STEAP4, two endosomal membrane proteins, while they are transported through the membrane. The electron donor partner of the enzyme is NADPH (Ohgami et al., 2005; Ohgami et al., 2006; Kleven et al., 2015; Oosterheert et al., 2018).
Literature References
PubMed ID Title Journal Year
16227996 Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

Fleming, MD, Ohgami, RS, Fujiwara, Y, Chen, J, Antiochos, B, Greer, EL, Campagna, DR, Barker, JE, McDonald, A, Sharp, JJ

Nat Genet 2005
30337524 Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

Oosterheert, W, Granneman, J, Mattevi, A, van Bezouwen, LS, Gros, P, Förster, F, Rodenburg, RNP

Nat Commun 2018
26205815 Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins

Dlakić, M, Lawrence, CM, Kleven, MD

J Biol Chem 2015
16609065 The Steap proteins are metalloreductases

Fleming, MD, Ohgami, RS, Campagna, DR, McDonald, A

Blood 2006
Participants
Participates
Catalyst Activity

ferric-chelate reductase (NADPH) activity of STEAP3,STEAP4 [endosome membrane]

Orthologous Events
Cross References
RHEA
Authored
Reviewed
Created
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