Reactome | STEAP3-like proteins reduce Fe3+ to Fe2+

STEAP3-like proteins reduce Fe3+ to Fe2+

Stable Identifier

R-HSA-917811

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endosome lumen, endosome membrane

Synonyms

Reduction of Fe3+ in the endosome

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STEAP3-like proteins reduce Fe3+ to Fe2+

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The iron ions that are no longer bound to transferrin are reduced by the metalloreductase STEAP3, an endosomal membrane protein. The electron donor partner of the enzyme is unknown (Ohgami et al, 2005; Ohgami et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16609065	The Steap proteins are metalloreductases Ohgami, RS, Campagna, DR, McDonald, A, Fleming, MD	Blood	2006
16227996	Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells Ohgami, RS, Campagna, DR, Greer, EL, Antiochos, B, McDonald, A, Chen, J, Sharp, JJ, Fujiwara, Y, Barker, JE, Fleming, MD	Nat Genet	2005