Reactome | Recruitment of IFNAR1

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Recruitment of IFNAR1 Show undefined attributes

authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:909728] Garapati, P V, 2010-07-07
dbId	909724
displayName	Recruitment of IFNAR1
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-909733] Interferon alpha/beta signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-912680] Inhibition of JAK kinase activity by SOCS1/3 - Homo sapiens [Reaction:R-HSA-909729] Activation of JAK kinases - Homo sapiens
input	[Complex:R-HSA-918195] IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] [Complex:R-HSA-909708] IFNAR1:TYK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:909634] Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site [LiteratureReference:909625] Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity [LiteratureReference:909628] Ligand-induced assembling of the type I interferon receptor on supported lipid bilayers [LiteratureReference:909583] The receptor of the type I interferon family
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Recruitment of IFNAR1
orthologousEvent	[Reaction:R-GGA-909724] Recruitment of IFNAR1 - Gallus gallus [Reaction:R-DRE-909724] Recruitment of IFNAR1 - Danio rerio [Reaction:R-SSC-909724] Recruitment of IFNAR1 - Sus scrofa [Reaction:R-BTA-909724] Recruitment of IFNAR1 - Bos taurus [Reaction:R-CFA-909724] Recruitment of IFNAR1 - Canis familiaris [Reaction:R-RNO-909724] Recruitment of IFNAR1 - Rattus norvegicus [Reaction:R-MMU-909724] Recruitment of IFNAR1 - Mus musculus
output	[Complex:R-HSA-909703] IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-909720] IFN alpha/beta binds to IFNAR2 - Homo sapiens
regulatedBy	[NegativeRegulation:9691241] Negative regulation by 'IFNAR1:TYK2:TYK2 inhibitors [plasma membrane]'
regulationReference	[RegulationReference:9691243] Negative regulation by 'IFNAR1:TYK2:TYK2 inhibitors [plasma membrane]' Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-909724
summation	[Summation:909664] The extracellular domain of IFNAR1 is atypical, consisting o...
updateTrackers	[UpdateTracker:9776806] Update Tracker - [Reaction:909724] Recruitment of IFNAR1 - v74:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9776806] Update Tracker - [Reaction:909724] Recruitment of IFNAR1 - v74:[addRegulator]
(hasEvent)	[Pathway:R-HSA-909733] Interferon alpha/beta signaling
(precedingEvent)	[Reaction:R-HSA-912680] Inhibition of JAK kinase activity by SOCS1/3 [Reaction:R-HSA-909729] Activation of JAK kinases