The extracellular domain of IFNAR1 is atypical, consisting of a tandem array of four FNIII domains and the first three N-terminal FNIII domains are involved in ligand recognition. IFNAR1 is recruited to the binary complex (IFNA/B:IFNAR2) on the membrane to form the ternary complex (IFNAR2:IFNA/B:IFNAR1). TYK2 kinase is pre-associated with IFNAR1 and JAK1 with IFNAR2. The binding of IFNA/B to IFNA receptors brings these JAK kinase together, allowing cross-phosphorylation and kinase activation.
Cajean-Feroldi, C, Nosal, F, Nardeux, PC, Gallet, X, Guymarho, J, Baychelier, F, Sempé, P, Tovey, MG, Escary, JL, Eid, P
Roisman, LC, Jaitin, DA, Baker, DP, Schreiber, G
Uzé, G, Schreiber, G, Piehler, J, Pellegrini, S
Lamken, P, Lata, S, Gavutis, M, Piehler, J
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