Reactome | Recruitment of IFNAR1

Recruitment of IFNAR1

Stable Identifier

R-HSA-909724

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The extracellular domain of IFNAR1 is atypical, consisting of a tandem array of four FNIII domains and the first three N-terminal FNIII domains are involved in ligand recognition. IFNAR1 is recruited to the binary complex (IFNA/B:IFNAR2) on the membrane to form the ternary complex (IFNAR2:IFNA/B:IFNAR1). TYK2 kinase is pre-associated with IFNAR1 and JAK1 with IFNAR2. The binding of IFNA/B to IFNA receptors brings these JAK kinase together, allowing cross-phosphorylation and kinase activation.

Literature References

PubMed ID	Title	Journal	Year
15449939	Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity Cajean-Feroldi, C, Nosal, F, Nardeux, PC, Gallet, X, Guymarho, J, Baychelier, F, Sempé, P, Tovey, MG, Escary, JL, Eid, P	Biochemistry	2004
16171819	Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site Roisman, LC, Jaitin, DA, Baker, DP, Schreiber, G	J Mol Biol	2005
17969444	The receptor of the type I interferon family Uzé, G, Schreiber, G, Piehler, J, Pellegrini, S	Curr Top Microbiol Immunol	2007
15312780	Ligand-induced assembling of the type I interferon receptor on supported lipid bilayers Lamken, P, Lata, S, Gavutis, M, Piehler, J	J Mol Biol	2004