Reactome | Interferon alpha/beta signaling

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Interferon alpha/beta signaling Show undefined attributes

authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
created	[InstanceEdit:909734] Garapati, P V, 2010-07-07
crossReference	[DatabaseIdentifier:12325642] BioModels Database:BIOMD0000000968 [DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477
dbId	909733
displayName	Interferon alpha/beta signaling
doi	10.3180/R-HSA-909733.6
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-913531] Interferon Signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:383670] type I interferon signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-909720] IFN alpha/beta binds to IFNAR2 - Homo sapiens [Reaction:R-HSA-9696179] IFNAR2:JAK1:STAT2 binds type 1 interferon analogs - Homo sapiens [Reaction:R-HSA-9678935] IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors - Homo sapiens [Reaction:R-HSA-909724] Recruitment of IFNAR1 - Homo sapiens [Reaction:R-HSA-9678737] IFNAR1:TYK2 binds TYK2 inhibitors - Homo sapiens [Reaction:R-HSA-909729] Activation of JAK kinases - Homo sapiens [Reaction:R-HSA-909730] Phosphorylation of INFAR1 by TYK2 - Homo sapiens [Reaction:R-HSA-909719] Recruitment of STAT2 to p-IFNAR1 - Homo sapiens [Reaction:R-HSA-909732] Phosphorylation of STAT2 - Homo sapiens [Reaction:R-HSA-909726] Phosphorylation of STAT1 - Homo sapiens [Reaction:R-HSA-909722] Release of p-STAT2:p-STAT1 dimer - Homo sapiens [Reaction:R-HSA-909725] Interaction of IRF9 with p-STAT2:p-STAT1 - Homo sapiens [Reaction:R-HSA-909718] Formation of p-STAT1 homodimer - Homo sapiens [Reaction:R-HSA-9710959] p-STAT1 dimer binds KPNA1 - Homo sapiens [Reaction:R-HSA-9710963] p-STAT1dimer:KPNA1 binds KPNB1 - Homo sapiens [Reaction:R-HSA-909721] Translocation of ISGF3 complex to nucleus - Homo sapiens [Reaction:R-HSA-913529] Translocation of p-STAT1:p-STAT1 dimer to nucleus - Homo sapiens [Reaction:R-HSA-1015699] ISGF3 binds the ISRE promoter elements in IFN-stimulated genes - Homo sapiens [BlackBoxEvent:R-HSA-1015702] Expression of IFN-induced genes - Homo sapiens [Pathway:R-HSA-912694] Regulation of IFNA/IFNB signaling - Homo sapiens [Reaction:R-HSA-5223305] ABCE1 binds RNASEL, inhibiting it - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:909583] The receptor of the type I interferon family [LiteratureReference:909642] Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase [LiteratureReference:909612] Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein [LiteratureReference:909588] Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	Interferon alpha/beta signaling
orthologousEvent	[Pathway:R-MMU-909733] Interferon alpha/beta signaling - Mus musculus [Pathway:R-CFA-909733] Interferon alpha/beta signaling - Canis familiaris [Pathway:R-BTA-909733] Interferon alpha/beta signaling - Bos taurus [Pathway:R-SSC-909733] Interferon alpha/beta signaling - Sus scrofa [Pathway:R-XTR-909733] Interferon alpha/beta signaling - Xenopus tropicalis [Pathway:R-DME-909733] Interferon alpha/beta signaling - Drosophila melanogaster [Pathway:R-DDI-909733] Interferon alpha/beta signaling - Dictyostelium discoideum [Pathway:R-GGA-909733] Interferon alpha/beta signaling - Gallus gallus [Pathway:R-CEL-909733] Interferon alpha/beta signaling - Caenorhabditis elegans [Pathway:R-RNO-909733] Interferon alpha/beta signaling - Rattus norvegicus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-909733
summation	[Summation:913488] Type I interferons (IFNs) are composed of various genes incl...

Referrals

(hasEvent)	[Pathway:R-HSA-913531] Interferon Signaling
(hasEncapsulatedEvent)	[Pathway:R-HSA-9692914] SARS-CoV-1-host interactions [Pathway:R-HSA-9833482] PKR-mediated signaling [Pathway:R-HSA-9833110] RSV-host interactions [Pathway:R-HSA-9705683] SARS-CoV-2-host interactions

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